STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SUN2Sad1 and UNC84 domain containing 2. (728 aa)    
Predicted Functional Partners:
SYNE2
Spectrin repeat containing nuclear envelope protein 2.
    
 0.994
CCDC155
Protein KASH5; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redunda [...]
    
 0.989
SYNE1
Spectrin repeat containing nuclear envelope protein 1.
   
 
 0.979
SYNE4
Spectrin repeat containing nuclear envelope family member 4.
    
 0.949
EMD
EMD protein.
    
 
 0.933
LMNA
Lamin A/C; Belongs to the intermediate filament family.
    
 
 0.928
SYNE3
Spectrin repeat containing nuclear envelope family member 3.
    
 0.876
LMNB1
LMNB1 protein; Belongs to the intermediate filament family.
    
 
 0.867
SUN1
Sad1 and UNC84 domain containing 1.
  
 
0.861
LMNB2
Lamin B2; Belongs to the intermediate filament family.
    
 
 0.858
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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