| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSBTAP00000062117 | MCU | ENSBTAP00000062117 | ENSBTAP00000005059 | Uncharacterized protein. | Mitochondrial calcium uniporter. | 0.830 |
| ENSBTAP00000062117 | MCUB | ENSBTAP00000062117 | ENSBTAP00000017276 | Uncharacterized protein. | Mitochondrial calcium uniporter dominant negative beta subunit. | 0.720 |
| ENSBTAP00000062117 | MICU1 | ENSBTAP00000062117 | ENSBTAP00000007636 | Uncharacterized protein. | Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...] | 0.814 |
| ENSBTAP00000062117 | MICU2 | ENSBTAP00000062117 | ENSBTAP00000062719 | Uncharacterized protein. | Mitochondrial calcium uptake 2. | 0.788 |
| ENSBTAP00000062117 | MICU3 | ENSBTAP00000062117 | ENSBTAP00000039694 | Uncharacterized protein. | Mitochondrial calcium uptake family member 3. | 0.681 |
| LETM1 | MCU | ENSBTAP00000026785 | ENSBTAP00000005059 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family. | Mitochondrial calcium uniporter. | 0.796 |
| LETM1 | MCUB | ENSBTAP00000026785 | ENSBTAP00000017276 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family. | Mitochondrial calcium uniporter dominant negative beta subunit. | 0.582 |
| LETM1 | MCUR1 | ENSBTAP00000026785 | ENSBTAP00000070688 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family. | Mitochondrial calcium uniporter regulator 1. | 0.694 |
| LETM1 | MICU1 | ENSBTAP00000026785 | ENSBTAP00000007636 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family. | Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...] | 0.827 |
| LETM1 | MICU2 | ENSBTAP00000026785 | ENSBTAP00000062719 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family. | Mitochondrial calcium uptake 2. | 0.753 |
| LETM1 | MICU3 | ENSBTAP00000026785 | ENSBTAP00000039694 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family. | Mitochondrial calcium uptake family member 3. | 0.512 |
| LETM1 | SPG7 | ENSBTAP00000026785 | ENSBTAP00000032431 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family. | SPG7 matrix AAA peptidase subunit, paraplegin. | 0.439 |
| MCU | ENSBTAP00000062117 | ENSBTAP00000005059 | ENSBTAP00000062117 | Mitochondrial calcium uniporter. | Uncharacterized protein. | 0.830 |
| MCU | LETM1 | ENSBTAP00000005059 | ENSBTAP00000026785 | Mitochondrial calcium uniporter. | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family. | 0.796 |
| MCU | MCUB | ENSBTAP00000005059 | ENSBTAP00000017276 | Mitochondrial calcium uniporter. | Mitochondrial calcium uniporter dominant negative beta subunit. | 0.954 |
| MCU | MCUR1 | ENSBTAP00000005059 | ENSBTAP00000070688 | Mitochondrial calcium uniporter. | Mitochondrial calcium uniporter regulator 1. | 0.929 |
| MCU | MICU1 | ENSBTAP00000005059 | ENSBTAP00000007636 | Mitochondrial calcium uniporter. | Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...] | 0.999 |
| MCU | MICU2 | ENSBTAP00000005059 | ENSBTAP00000062719 | Mitochondrial calcium uniporter. | Mitochondrial calcium uptake 2. | 0.989 |
| MCU | MICU3 | ENSBTAP00000005059 | ENSBTAP00000039694 | Mitochondrial calcium uniporter. | Mitochondrial calcium uptake family member 3. | 0.974 |
| MCU | NDUFA9 | ENSBTAP00000005059 | ENSBTAP00000007189 | Mitochondrial calcium uniporter. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.767 |
