node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AACS | ACAA1 | ENSBTAP00000007459 | ENSBTAP00000024335 | Acetoacetyl-CoA synthetase. | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.618 |
AACS | ACAT1 | ENSBTAP00000007459 | ENSBTAP00000017122 | Acetoacetyl-CoA synthetase. | Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] | 0.968 |
AACS | ACAT2 | ENSBTAP00000007459 | ENSBTAP00000003660 | Acetoacetyl-CoA synthetase. | Acetyl-Coenzyme A acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.953 |
AACS | EHHADH | ENSBTAP00000007459 | ENSBTAP00000053200 | Acetoacetyl-CoA synthetase. | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. | 0.942 |
AACS | HADHB | ENSBTAP00000007459 | ENSBTAP00000070545 | Acetoacetyl-CoA synthetase. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] | 0.561 |
AACS | HMGCL | ENSBTAP00000007459 | ENSBTAP00000029103 | Acetoacetyl-CoA synthetase. | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. | 0.964 |
AACS | HMGCLL1 | ENSBTAP00000007459 | ENSBTAP00000019954 | Acetoacetyl-CoA synthetase. | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. | 0.946 |
AACS | HMGCR | ENSBTAP00000007459 | ENSBTAP00000010315 | Acetoacetyl-CoA synthetase. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | 0.532 |
AACS | HMGCS2 | ENSBTAP00000007459 | ENSBTAP00000005088 | Acetoacetyl-CoA synthetase. | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. | 0.953 |
AACS | OXCT1 | ENSBTAP00000007459 | ENSBTAP00000059174 | Acetoacetyl-CoA synthetase. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.930 |
ACAA1 | AACS | ENSBTAP00000024335 | ENSBTAP00000007459 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetoacetyl-CoA synthetase. | 0.618 |
ACAA1 | ACAT1 | ENSBTAP00000024335 | ENSBTAP00000017122 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] | 0.955 |
ACAA1 | ACAT2 | ENSBTAP00000024335 | ENSBTAP00000003660 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-Coenzyme A acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.913 |
ACAA1 | EHHADH | ENSBTAP00000024335 | ENSBTAP00000053200 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. | 0.996 |
ACAA1 | HADHB | ENSBTAP00000024335 | ENSBTAP00000070545 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] | 0.948 |
ACAA1 | HMGCL | ENSBTAP00000024335 | ENSBTAP00000029103 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. | 0.958 |
ACAA1 | HMGCLL1 | ENSBTAP00000024335 | ENSBTAP00000019954 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. | 0.938 |
ACAA1 | HMGCR | ENSBTAP00000024335 | ENSBTAP00000010315 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | 0.401 |
ACAA1 | HMGCS2 | ENSBTAP00000024335 | ENSBTAP00000005088 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. | 0.989 |
ACAA1 | OXCT1 | ENSBTAP00000024335 | ENSBTAP00000059174 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.943 |