STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MVB12AMultivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity); Belongs to the MVB12 family. (273 aa)    
Predicted Functional Partners:
VPS28
Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
   
 0.993
VPS37B
VPS37 C-terminal domain-containing protein.
   
 0.986
TSG101
Tumor susceptibility 101.
    
 0.985
VPS37A
Vacuolar protein sorting 37 homolog A (S. cerevisiae).
   
 0.965
PDCD6IP
Programmed cell death 6 interacting protein.
     
 0.962
VPS37C
VPS37C subunit of ESCRT-I.
   
 0.958
VPS37D
VPS37D subunit of ESCRT-I.
   
 0.951
MVB12B
Multivesicular body subunit 12B.
    
0.923
UBAP1
Ubiquitin associated protein 1.
     
 0.912
UEVLD
UEV and lactate/malate dehyrogenase domains.
    
 0.865
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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