node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
INPP5E | OCRL | ENSBTAP00000001784 | ENSBTAP00000024296 | Inositol polyphosphate-5-phosphatase E. | OCRL inositol polyphosphate-5-phosphatase. | 0.924 |
INPP5E | PIK3CA | ENSBTAP00000001784 | ENSBTAP00000068953 | Inositol polyphosphate-5-phosphatase E. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] | 0.900 |
INPP5E | PIK3CB | ENSBTAP00000001784 | ENSBTAP00000009083 | Inositol polyphosphate-5-phosphatase E. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.900 |
INPP5E | PIK3R2 | ENSBTAP00000001784 | ENSBTAP00000003033 | Inositol polyphosphate-5-phosphatase E. | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] | 0.698 |
INPP5E | PIK3R3 | ENSBTAP00000001784 | ENSBTAP00000003878 | Inositol polyphosphate-5-phosphatase E. | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. | 0.698 |
INPP5E | PIKFYVE | ENSBTAP00000001784 | ENSBTAP00000002824 | Inositol polyphosphate-5-phosphatase E. | Phosphoinositide kinase, FYVE-type zinc finger containing. | 0.504 |
INPP5E | PIP4K2A | ENSBTAP00000001784 | ENSBTAP00000024007 | Inositol polyphosphate-5-phosphatase E. | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. | 0.940 |
INPP5E | PIP4K2C | ENSBTAP00000001784 | ENSBTAP00000005146 | Inositol polyphosphate-5-phosphatase E. | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum. | 0.919 |
INPP5E | PIP4P1 | ENSBTAP00000001784 | ENSBTAP00000003561 | Inositol polyphosphate-5-phosphatase E. | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). | 0.902 |
INPP5E | PTEN | ENSBTAP00000001784 | ENSBTAP00000012499 | Inositol polyphosphate-5-phosphatase E. | Phosphatase and tensin homolog. | 0.910 |
OCRL | INPP5E | ENSBTAP00000024296 | ENSBTAP00000001784 | OCRL inositol polyphosphate-5-phosphatase. | Inositol polyphosphate-5-phosphatase E. | 0.924 |
OCRL | PIK3CA | ENSBTAP00000024296 | ENSBTAP00000068953 | OCRL inositol polyphosphate-5-phosphatase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] | 0.909 |
OCRL | PIK3CB | ENSBTAP00000024296 | ENSBTAP00000009083 | OCRL inositol polyphosphate-5-phosphatase. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.902 |
OCRL | PIK3R2 | ENSBTAP00000024296 | ENSBTAP00000003033 | OCRL inositol polyphosphate-5-phosphatase. | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] | 0.699 |
OCRL | PIK3R3 | ENSBTAP00000024296 | ENSBTAP00000003878 | OCRL inositol polyphosphate-5-phosphatase. | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. | 0.679 |
OCRL | PIKFYVE | ENSBTAP00000024296 | ENSBTAP00000002824 | OCRL inositol polyphosphate-5-phosphatase. | Phosphoinositide kinase, FYVE-type zinc finger containing. | 0.466 |
OCRL | PIP4K2A | ENSBTAP00000024296 | ENSBTAP00000024007 | OCRL inositol polyphosphate-5-phosphatase. | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. | 0.930 |
OCRL | PIP4K2C | ENSBTAP00000024296 | ENSBTAP00000005146 | OCRL inositol polyphosphate-5-phosphatase. | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum. | 0.937 |
OCRL | PIP4P1 | ENSBTAP00000024296 | ENSBTAP00000003561 | OCRL inositol polyphosphate-5-phosphatase. | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). | 0.901 |
OCRL | PTEN | ENSBTAP00000024296 | ENSBTAP00000012499 | OCRL inositol polyphosphate-5-phosphatase. | Phosphatase and tensin homolog. | 0.924 |