Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
BTCProbetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). (178 aa)    
Predicted Functional Partners:
EGFR
Receptor protein-tyrosine kinase.
   
 0.996
ERBB4
Receptor protein-tyrosine kinase.
    
 0.990
ERBB2
Receptor protein-tyrosine kinase.
    
 0.964
AREG
Amphiregulin.
     
 0.963
ERBB3
Erb-b2 receptor tyrosine kinase 3.
    
 0.962
HBEGF
Heparin binding EGF like growth factor.
     
 0.921
ENSBTAP00000074593
Uncharacterized protein.
    
 0.823
EREG
Epiregulin.
     
0.812
EPGN
Epithelial mitogen.
     
 0.802
NRG1
Neuregulin 1.
     
 0.752
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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