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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BTCProbetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). (178 aa)    
Predicted Functional Partners:
EGFR
Receptor protein-tyrosine kinase.
   
 0.996
ERBB4
Receptor protein-tyrosine kinase.
    
 0.995
AREG
Amphiregulin.
     
 0.954
HBEGF
Heparin binding EGF like growth factor.
     
 0.943
ERBB3
Erb-b2 receptor tyrosine kinase 3.
    
 0.901
ERBB2
Receptor protein-tyrosine kinase.
    
 0.803
EPGN
Epithelial mitogen.
     
 0.802
EREG
Epiregulin.
     
0.791
NRG1
Neuregulin 1.
     
 0.769
NRG2
Neuregulin 2.
     
 0.761
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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