node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMD1 | AOC1 | ENSBTAP00000065674 | ENSBTAP00000007133 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Amine oxidase. | 0.539 |
AMD1 | ARG1 | ENSBTAP00000065674 | ENSBTAP00000016461 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Arginase-1. | 0.607 |
AMD1 | ARG2 | ENSBTAP00000065674 | ENSBTAP00000053934 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.773 |
AMD1 | OAT | ENSBTAP00000065674 | ENSBTAP00000009097 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Ornithine aminotransferase, mitochondrial. | 0.441 |
AMD1 | ODC1 | ENSBTAP00000065674 | ENSBTAP00000005575 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.950 |
AMD1 | SAT1 | ENSBTAP00000065674 | ENSBTAP00000023087 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine (By similarity). | 0.786 |
AMD1 | SMS | ENSBTAP00000065674 | ENSBTAP00000071420 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). | 0.996 |
AMD1 | SRM | ENSBTAP00000065674 | ENSBTAP00000006978 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.996 |
AOC1 | AMD1 | ENSBTAP00000007133 | ENSBTAP00000065674 | Amine oxidase. | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | 0.539 |
AOC1 | ODC1 | ENSBTAP00000007133 | ENSBTAP00000005575 | Amine oxidase. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.959 |
AOC1 | SAT1 | ENSBTAP00000007133 | ENSBTAP00000023087 | Amine oxidase. | Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine (By similarity). | 0.919 |
AOC1 | SAT2 | ENSBTAP00000007133 | ENSBTAP00000005531 | Amine oxidase. | Diamine acetyltransferase 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine (By similarity). | 0.900 |
AOC1 | SMS | ENSBTAP00000007133 | ENSBTAP00000071420 | Amine oxidase. | Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). | 0.481 |
AOC1 | SRM | ENSBTAP00000007133 | ENSBTAP00000006978 | Amine oxidase. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.948 |
ARG1 | AMD1 | ENSBTAP00000016461 | ENSBTAP00000065674 | Arginase-1. | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | 0.607 |
ARG1 | ARG2 | ENSBTAP00000016461 | ENSBTAP00000053934 | Arginase-1. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.911 |
ARG1 | OAT | ENSBTAP00000016461 | ENSBTAP00000009097 | Arginase-1. | Ornithine aminotransferase, mitochondrial. | 0.998 |
ARG1 | ODC1 | ENSBTAP00000016461 | ENSBTAP00000005575 | Arginase-1. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.983 |
ARG1 | SMS | ENSBTAP00000016461 | ENSBTAP00000071420 | Arginase-1. | Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). | 0.869 |
ARG1 | SRM | ENSBTAP00000016461 | ENSBTAP00000006978 | Arginase-1. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.887 |