node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPL | BGLAP | ENSBTAP00000067523 | ENSBTAP00000047703 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.843 |
ALPL | BMP2 | ENSBTAP00000067523 | ENSBTAP00000006739 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Bone morphogenetic protein 2. | 0.674 |
ALPL | COL1A1 | ENSBTAP00000067523 | ENSBTAP00000017420 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.789 |
ALPL | DLX5 | ENSBTAP00000067523 | ENSBTAP00000024811 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Distal-less homeobox 5. | 0.574 |
ALPL | IBSP | ENSBTAP00000067523 | ENSBTAP00000000595 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). | 0.780 |
ALPL | RUNX2 | ENSBTAP00000067523 | ENSBTAP00000072258 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.867 |
ALPL | SP7 | ENSBTAP00000067523 | ENSBTAP00000005689 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Sp7 transcription factor. | 0.774 |
ALPL | SPP1 | ENSBTAP00000067523 | ENSBTAP00000062863 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. | 0.743 |
BGLAP | ALPL | ENSBTAP00000047703 | ENSBTAP00000067523 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | 0.843 |
BGLAP | BMP2 | ENSBTAP00000047703 | ENSBTAP00000006739 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Bone morphogenetic protein 2. | 0.891 |
BGLAP | COL1A1 | ENSBTAP00000047703 | ENSBTAP00000017420 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.866 |
BGLAP | DLX5 | ENSBTAP00000047703 | ENSBTAP00000024811 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Distal-less homeobox 5. | 0.824 |
BGLAP | IBSP | ENSBTAP00000047703 | ENSBTAP00000000595 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). | 0.852 |
BGLAP | RUNX2 | ENSBTAP00000047703 | ENSBTAP00000072258 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.939 |
BGLAP | SP7 | ENSBTAP00000047703 | ENSBTAP00000005689 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Sp7 transcription factor. | 0.776 |
BGLAP | SPP1 | ENSBTAP00000047703 | ENSBTAP00000062863 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. | 0.962 |
BMP2 | ALPL | ENSBTAP00000006739 | ENSBTAP00000067523 | Bone morphogenetic protein 2. | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | 0.674 |
BMP2 | BGLAP | ENSBTAP00000006739 | ENSBTAP00000047703 | Bone morphogenetic protein 2. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.891 |
BMP2 | COL1A1 | ENSBTAP00000006739 | ENSBTAP00000017420 | Bone morphogenetic protein 2. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.728 |
BMP2 | DLX5 | ENSBTAP00000006739 | ENSBTAP00000024811 | Bone morphogenetic protein 2. | Distal-less homeobox 5. | 0.674 |