STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPYPro-neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone (97 aa)    
Predicted Functional Partners:
POMC
Pro-opiomelanocortin; Corticotropin: Stimulates the adrenal glands to release cortisol
   
 
 0.994
NPY1R
Neuropeptide Y receptor type 1; Receptor for neuropeptide Y and peptide YY
    
 0.992
NPY2R
Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY
   
 0.989
SST
Somatostatin; Somatostatin inhibits the release of somatotropin
   
 
 0.989
PPY
Pancreatic polypeptide; Belongs to the NPY family
     
 0.983
NPY5R
Bos taurus neuropeptide Y receptor Y5 (NPY5R), mRNA
   
 0.981
PMCH
Bos taurus pro-melanin-concentrating hormone (PMCH), mRNA
   
 0.970
PENK
Proenkephalin-A; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(111-130) and PENK(233-254) increase glutamate release in the striatum. PENK(111-130) decreases GABA concentration in the striatum; Belongs to the opioid neuropeptide precursor family
   
 
 0.967
GAL
Galanin peptides; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion
     
 0.967
PPYR1
Uncharacterized protein; Bos taurus pancreatic polypeptide receptor 1 (PPYR1), mRNA; Belongs to the G-protein coupled receptor 1 family
    
 0.962
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, domestic cattle, domestic cow
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