node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2 | FLT3 | ENSBTAP00000025701 | ENSBTAP00000024717 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.575 |
BCL2 | MDM2 | ENSBTAP00000025701 | ENSBTAP00000072778 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.906 |
BCL2 | PIM2 | ENSBTAP00000025701 | ENSBTAP00000006032 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. | 0.521 |
BCL2 | TSC2 | ENSBTAP00000025701 | ENSBTAP00000046373 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | TSC complex subunit 2. | 0.566 |
CRNKL1 | KANSL2 | ENSBTAP00000011148 | ENSBTAP00000051777 | Crooked neck pre-mRNA splicing factor 1. | KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. | 0.776 |
CRNKL1 | PIM2 | ENSBTAP00000011148 | ENSBTAP00000006032 | Crooked neck pre-mRNA splicing factor 1. | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. | 0.661 |
CRNKL1 | PRCC | ENSBTAP00000011148 | ENSBTAP00000000800 | Crooked neck pre-mRNA splicing factor 1. | Papillary renal cell carcinoma (Translocation-associated). | 0.954 |
CRNKL1 | ZNF830 | ENSBTAP00000011148 | ENSBTAP00000027106 | Crooked neck pre-mRNA splicing factor 1. | Zinc finger protein 830. | 0.969 |
DDX6 | PIM1 | ENSBTAP00000011952 | ENSBTAP00000000511 | DEAD-box helicase 6; Belongs to the DEAD box helicase family. | Serine/threonine-protein kinase pim-1; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly th [...] | 0.650 |
DDX6 | PIM2 | ENSBTAP00000011952 | ENSBTAP00000006032 | DEAD-box helicase 6; Belongs to the DEAD box helicase family. | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. | 0.532 |
FLT3 | BCL2 | ENSBTAP00000024717 | ENSBTAP00000025701 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | 0.575 |
FLT3 | PIM2 | ENSBTAP00000024717 | ENSBTAP00000006032 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. | 0.568 |
KANSL2 | CRNKL1 | ENSBTAP00000051777 | ENSBTAP00000011148 | KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. | Crooked neck pre-mRNA splicing factor 1. | 0.776 |
KANSL2 | PIM2 | ENSBTAP00000051777 | ENSBTAP00000006032 | KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. | 0.641 |
KANSL2 | PRCC | ENSBTAP00000051777 | ENSBTAP00000000800 | KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. | Papillary renal cell carcinoma (Translocation-associated). | 0.744 |
KANSL2 | ZNF830 | ENSBTAP00000051777 | ENSBTAP00000027106 | KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. | Zinc finger protein 830. | 0.807 |
MDM2 | BCL2 | ENSBTAP00000072778 | ENSBTAP00000025701 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | 0.906 |
MDM2 | PIM2 | ENSBTAP00000072778 | ENSBTAP00000006032 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. | 0.534 |
MDM2 | TSC2 | ENSBTAP00000072778 | ENSBTAP00000046373 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | TSC complex subunit 2. | 0.552 |
PIM1 | DDX6 | ENSBTAP00000000511 | ENSBTAP00000011952 | Serine/threonine-protein kinase pim-1; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly th [...] | DEAD-box helicase 6; Belongs to the DEAD box helicase family. | 0.650 |