node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CARMIL3 | CNKSR2 | ENSBTAP00000053203 | ENSBTAP00000053655 | Capping protein regulator and myosin 1 linker 3. | Connector enhancer of kinase suppressor of Ras 2. | 0.637 |
CARMIL3 | SRGAP3 | ENSBTAP00000053203 | ENSBTAP00000006152 | Capping protein regulator and myosin 1 linker 3. | SLIT-ROBO Rho GTPase activating protein 3. | 0.758 |
CDC42 | SRGAP1 | ENSBTAP00000059852 | ENSBTAP00000015786 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | SLIT-ROBO Rho GTPase activating protein 1. | 0.960 |
CDC42 | SRGAP2 | ENSBTAP00000059852 | ENSBTAP00000058133 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Uncharacterized protein. | 0.956 |
CDC42 | SRGAP3 | ENSBTAP00000059852 | ENSBTAP00000006152 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | SLIT-ROBO Rho GTPase activating protein 3. | 0.934 |
CDC42 | WASL | ENSBTAP00000059852 | ENSBTAP00000006094 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.999 |
CNKSR2 | CARMIL3 | ENSBTAP00000053655 | ENSBTAP00000053203 | Connector enhancer of kinase suppressor of Ras 2. | Capping protein regulator and myosin 1 linker 3. | 0.637 |
CNKSR2 | SRGAP3 | ENSBTAP00000053655 | ENSBTAP00000006152 | Connector enhancer of kinase suppressor of Ras 2. | SLIT-ROBO Rho GTPase activating protein 3. | 0.695 |
KIAA1549 | SRGAP3 | ENSBTAP00000053500 | ENSBTAP00000006152 | KIAA1549. | SLIT-ROBO Rho GTPase activating protein 3. | 0.632 |
LHFPL4 | SRGAP3 | ENSBTAP00000044599 | ENSBTAP00000006152 | LHFPL tetraspan subfamily member 4 protein; Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma- aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. | SLIT-ROBO Rho GTPase activating protein 3. | 0.628 |
ROBO1 | ROBO2-2 | ENSBTAP00000053683 | ENSBTAP00000055088 | Roundabout guidance receptor 1. | Ig-like domain-containing protein. | 0.918 |
ROBO1 | SRGAP1 | ENSBTAP00000053683 | ENSBTAP00000015786 | Roundabout guidance receptor 1. | SLIT-ROBO Rho GTPase activating protein 1. | 0.974 |
ROBO1 | SRGAP2 | ENSBTAP00000053683 | ENSBTAP00000058133 | Roundabout guidance receptor 1. | Uncharacterized protein. | 0.943 |
ROBO1 | SRGAP3 | ENSBTAP00000053683 | ENSBTAP00000006152 | Roundabout guidance receptor 1. | SLIT-ROBO Rho GTPase activating protein 3. | 0.937 |
ROBO2-2 | ROBO1 | ENSBTAP00000055088 | ENSBTAP00000053683 | Ig-like domain-containing protein. | Roundabout guidance receptor 1. | 0.918 |
ROBO2-2 | SRGAP1 | ENSBTAP00000055088 | ENSBTAP00000015786 | Ig-like domain-containing protein. | SLIT-ROBO Rho GTPase activating protein 1. | 0.947 |
ROBO2-2 | SRGAP2 | ENSBTAP00000055088 | ENSBTAP00000058133 | Ig-like domain-containing protein. | Uncharacterized protein. | 0.940 |
ROBO2-2 | SRGAP3 | ENSBTAP00000055088 | ENSBTAP00000006152 | Ig-like domain-containing protein. | SLIT-ROBO Rho GTPase activating protein 3. | 0.923 |
SRGAP1 | CDC42 | ENSBTAP00000015786 | ENSBTAP00000059852 | SLIT-ROBO Rho GTPase activating protein 1. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.960 |
SRGAP1 | ROBO1 | ENSBTAP00000015786 | ENSBTAP00000053683 | SLIT-ROBO Rho GTPase activating protein 1. | Roundabout guidance receptor 1. | 0.974 |