node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AOPEP | ARL14EP | ENSBTAP00000000938 | ENSBTAP00000072039 | Leuk-A4-hydro_C domain-containing protein. | ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. | 0.766 |
AOPEP | NEIL2 | ENSBTAP00000000938 | ENSBTAP00000006262 | Leuk-A4-hydro_C domain-containing protein. | Endonuclease 8-like 2; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5- hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with [...] | 0.577 |
AOPEP | PLGRKT | ENSBTAP00000000938 | ENSBTAP00000023306 | Leuk-A4-hydro_C domain-containing protein. | Plasminogen receptor with a C-terminal lysine. | 0.690 |
ARL14EP | AOPEP | ENSBTAP00000072039 | ENSBTAP00000000938 | ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. | Leuk-A4-hydro_C domain-containing protein. | 0.766 |
ARL14EP | NEIL2 | ENSBTAP00000072039 | ENSBTAP00000006262 | ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. | Endonuclease 8-like 2; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5- hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with [...] | 0.624 |
ARL14EP | PLGRKT | ENSBTAP00000072039 | ENSBTAP00000023306 | ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. | Plasminogen receptor with a C-terminal lysine. | 0.748 |
KEAP1 | NEIL2 | ENSBTAP00000004604 | ENSBTAP00000006262 | Kelch like ECH associated protein 1. | Endonuclease 8-like 2; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5- hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with [...] | 0.679 |
KEAP1 | NFE2L2 | ENSBTAP00000004604 | ENSBTAP00000059632 | Kelch like ECH associated protein 1. | Nuclear factor erythroid 2-related factor 2; Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles. In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, hetero [...] | 0.999 |
LIG3 | NEIL1 | ENSBTAP00000056748 | ENSBTAP00000043635 | DNA ligase. | Nei like DNA glycosylase 1. | 0.831 |
LIG3 | NEIL2 | ENSBTAP00000056748 | ENSBTAP00000006262 | DNA ligase. | Endonuclease 8-like 2; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5- hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with [...] | 0.499 |
LIG3 | OGG1 | ENSBTAP00000056748 | ENSBTAP00000010226 | DNA ligase. | 8-oxoguanine DNA glycosylase. | 0.641 |
LIG3 | PNKP | ENSBTAP00000056748 | ENSBTAP00000002397 | DNA ligase. | Polynucleotide kinase 3'-phosphatase. | 0.935 |
LIG3 | POLB | ENSBTAP00000056748 | ENSBTAP00000060165 | DNA ligase. | DNA polymerase beta; Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity). | 0.956 |
NEIL1 | LIG3 | ENSBTAP00000043635 | ENSBTAP00000056748 | Nei like DNA glycosylase 1. | DNA ligase. | 0.831 |
NEIL1 | NEIL2 | ENSBTAP00000043635 | ENSBTAP00000006262 | Nei like DNA glycosylase 1. | Endonuclease 8-like 2; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5- hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with [...] | 0.930 |
NEIL1 | OGG1 | ENSBTAP00000043635 | ENSBTAP00000010226 | Nei like DNA glycosylase 1. | 8-oxoguanine DNA glycosylase. | 0.960 |
NEIL1 | PNKP | ENSBTAP00000043635 | ENSBTAP00000002397 | Nei like DNA glycosylase 1. | Polynucleotide kinase 3'-phosphatase. | 0.889 |
NEIL1 | POLB | ENSBTAP00000043635 | ENSBTAP00000060165 | Nei like DNA glycosylase 1. | DNA polymerase beta; Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity). | 0.938 |
NEIL2 | AOPEP | ENSBTAP00000006262 | ENSBTAP00000000938 | Endonuclease 8-like 2; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5- hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with [...] | Leuk-A4-hydro_C domain-containing protein. | 0.577 |
NEIL2 | ARL14EP | ENSBTAP00000006262 | ENSBTAP00000072039 | Endonuclease 8-like 2; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5- hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with [...] | ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. | 0.624 |