node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HYPK | NAA10 | ENSBTAP00000022876 | ENSBTAP00000055621 | Huntingtin interacting protein K. | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | 0.956 |
HYPK | NAA11 | ENSBTAP00000022876 | ENSBTAP00000017477 | Huntingtin interacting protein K. | N(alpha)-acetyltransferase 11, NatA catalytic subunit. | 0.883 |
HYPK | NAA15 | ENSBTAP00000022876 | ENSBTAP00000045426 | Huntingtin interacting protein K. | N(alpha)-acetyltransferase 15, NatA auxiliary subunit. | 0.897 |
HYPK | NAA40 | ENSBTAP00000022876 | ENSBTAP00000003996 | Huntingtin interacting protein K. | N(alpha)-acetyltransferase 40, NatD catalytic subunit. | 0.558 |
HYPK | NAA50 | ENSBTAP00000022876 | ENSBTAP00000031032 | Huntingtin interacting protein K. | N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...] | 0.979 |
HYPK | NAA60 | ENSBTAP00000022876 | ENSBTAP00000058359 | Huntingtin interacting protein K. | N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N- terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences; Belongs to the ace [...] | 0.881 |
HYPK | NAA80 | ENSBTAP00000022876 | ENSBTAP00000048695 | Huntingtin interacting protein K. | N(alpha)-acetyltransferase 80, NatH catalytic subunit. | 0.686 |
NAA10 | HYPK | ENSBTAP00000055621 | ENSBTAP00000022876 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | Huntingtin interacting protein K. | 0.956 |
NAA10 | NAA11 | ENSBTAP00000055621 | ENSBTAP00000017477 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | N(alpha)-acetyltransferase 11, NatA catalytic subunit. | 0.549 |
NAA10 | NAA15 | ENSBTAP00000055621 | ENSBTAP00000045426 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | N(alpha)-acetyltransferase 15, NatA auxiliary subunit. | 0.982 |
NAA10 | NAA40 | ENSBTAP00000055621 | ENSBTAP00000003996 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | N(alpha)-acetyltransferase 40, NatD catalytic subunit. | 0.647 |
NAA10 | NAA50 | ENSBTAP00000055621 | ENSBTAP00000031032 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...] | 0.988 |
NAA10 | NAA60 | ENSBTAP00000055621 | ENSBTAP00000058359 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N- terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences; Belongs to the ace [...] | 0.931 |
NAA10 | NAA80 | ENSBTAP00000055621 | ENSBTAP00000048695 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | N(alpha)-acetyltransferase 80, NatH catalytic subunit. | 0.728 |
NAA11 | HYPK | ENSBTAP00000017477 | ENSBTAP00000022876 | N(alpha)-acetyltransferase 11, NatA catalytic subunit. | Huntingtin interacting protein K. | 0.883 |
NAA11 | NAA10 | ENSBTAP00000017477 | ENSBTAP00000055621 | N(alpha)-acetyltransferase 11, NatA catalytic subunit. | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | 0.549 |
NAA11 | NAA15 | ENSBTAP00000017477 | ENSBTAP00000045426 | N(alpha)-acetyltransferase 11, NatA catalytic subunit. | N(alpha)-acetyltransferase 15, NatA auxiliary subunit. | 0.903 |
NAA11 | NAA40 | ENSBTAP00000017477 | ENSBTAP00000003996 | N(alpha)-acetyltransferase 11, NatA catalytic subunit. | N(alpha)-acetyltransferase 40, NatD catalytic subunit. | 0.410 |
NAA11 | NAA50 | ENSBTAP00000017477 | ENSBTAP00000031032 | N(alpha)-acetyltransferase 11, NatA catalytic subunit. | N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...] | 0.961 |
NAA11 | NAA60 | ENSBTAP00000017477 | ENSBTAP00000058359 | N(alpha)-acetyltransferase 11, NatA catalytic subunit. | N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N- terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences; Belongs to the ace [...] | 0.652 |