STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT15KRT15 protein; Belongs to the intermediate filament family. (453 aa)    
Predicted Functional Partners:
LGR6
Leucine rich repeat containing G protein-coupled receptor 6.
      
 0.682
LRIG1
Leucine rich repeats and immunoglobulin like domains 1.
    
 
 0.660
KRT4
KRT4 protein; Belongs to the intermediate filament family.
  
 
0.639
CCDC153
Coiled-coil domain-containing protein 153; Belongs to the UPF0610 family.
      
 0.599
LYPD3
LY6/PLAUR domain containing 3.
   
  
 0.599
LOR
Uncharacterized protein.
   
 
 0.598
C10H15orf48
Chromosome 10 C15orf48 homolog.
      
 0.569
COL17A1
120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.
   
 
 0.501
KRT17
Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...]
  
 
0.488
KRT14
Keratin, type I cytoskeletal 14; Belongs to the intermediate filament family.
  
 
0.487
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.