node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTA1 | MB | ENSBTAP00000006532 | ENSBTAP00000007014 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | 0.938 |
ACTA1 | MYH1 | ENSBTAP00000006532 | ENSBTAP00000009327 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin-1; Muscle contraction. | 0.842 |
ACTA1 | MYH7 | ENSBTAP00000006532 | ENSBTAP00000053217 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.997 |
ACTA1 | MYL1 | ENSBTAP00000006532 | ENSBTAP00000049636 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.932 |
ACTA1 | MYO6 | ENSBTAP00000006532 | ENSBTAP00000022276 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro- survival pathway. Appears to be i [...] | 0.851 |
ACTA1 | PFN1 | ENSBTAP00000006532 | ENSBTAP00000006465 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). | 0.868 |
ACTA1 | TNNT1 | ENSBTAP00000006532 | ENSBTAP00000073026 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.859 |
ACTA1 | TPM1 | ENSBTAP00000006532 | ENSBTAP00000063733 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Tropomyosin alpha-1 chain; Belongs to the tropomyosin family. | 0.974 |
ACTA1 | TPM2 | ENSBTAP00000006532 | ENSBTAP00000043502 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization; Belongs to the tropomyosin family. | 0.800 |
ACTA1 | VASP | ENSBTAP00000006532 | ENSBTAP00000026119 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...] | 0.806 |
MB | ACTA1 | ENSBTAP00000007014 | ENSBTAP00000006532 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | 0.938 |
MB | MYH1 | ENSBTAP00000007014 | ENSBTAP00000009327 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Myosin-1; Muscle contraction. | 0.824 |
MB | MYH7 | ENSBTAP00000007014 | ENSBTAP00000053217 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.946 |
MB | MYL1 | ENSBTAP00000007014 | ENSBTAP00000049636 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.843 |
MB | TNNT1 | ENSBTAP00000007014 | ENSBTAP00000073026 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.942 |
MYH1 | ACTA1 | ENSBTAP00000009327 | ENSBTAP00000006532 | Myosin-1; Muscle contraction. | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | 0.842 |
MYH1 | MB | ENSBTAP00000009327 | ENSBTAP00000007014 | Myosin-1; Muscle contraction. | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | 0.824 |
MYH1 | MYH7 | ENSBTAP00000009327 | ENSBTAP00000053217 | Myosin-1; Muscle contraction. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.839 |
MYH1 | MYL1 | ENSBTAP00000009327 | ENSBTAP00000049636 | Myosin-1; Muscle contraction. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.919 |
MYH1 | TNNT1 | ENSBTAP00000009327 | ENSBTAP00000073026 | Myosin-1; Muscle contraction. | Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.847 |