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MMAB protein (Bos taurus) - STRING interaction network
"MMAB" - Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial in Bos taurus
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MMABCob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial; Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA (241 aa)    
Predicted Functional Partners:
MMADHC
Bos taurus methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria (MMADHC), mRNA (296 aa)
           
  0.918
MMAA
Bos taurus methylmalonic aciduria (cobalamin deficiency) cblA type (MMAA), mRNA (421 aa)
   
   
  0.911
MMACHC
Methylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin [...] (280 aa)
     
   
  0.850
MUT
Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; Belongs to the methylmalonyl-CoA mutase family (750 aa)
         
  0.840
LMBRD1
Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity) (543 aa)
           
  0.812
MTRR
Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects (By similarity) (695 aa)
       
 
  0.772
MVK
Mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway; Belongs to the GHMP kinase family. Mevalonate kinase subfamily (440 aa)
     
   
  0.688
MMD
Uncharacterized protein; Bos taurus monocyte to macrophage differentiation-associated (MMD), mRNA (238 aa)
           
  0.680
DDI2
DNA-damage inducible 1 homolog 2 (S. cerevisiae) (399 aa)
           
  0.659
TMEM194B
Nuclear envelope integral membrane protein 2; Transmembrane protein 194B (425 aa)
           
  0.659
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, domestic cattle, domestic cow
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