node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PEX10 | PEX12 | ENSBTAP00000067889 | ENSBTAP00000026285 | Pex2_Pex12 domain-containing protein. | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | 0.999 |
PEX10 | PEX13 | ENSBTAP00000067889 | ENSBTAP00000006917 | Pex2_Pex12 domain-containing protein. | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). | 0.992 |
PEX10 | PEX14 | ENSBTAP00000067889 | ENSBTAP00000058256 | Pex2_Pex12 domain-containing protein. | Peroxisomal biogenesis factor 14. | 0.966 |
PEX10 | PEX16 | ENSBTAP00000067889 | ENSBTAP00000072447 | Pex2_Pex12 domain-containing protein. | Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity); Belongs to the peroxin-16 family. | 0.900 |
PEX10 | PEX19 | ENSBTAP00000067889 | ENSBTAP00000009921 | Pex2_Pex12 domain-containing protein. | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity). | 0.989 |
PEX10 | PEX2 | ENSBTAP00000067889 | ENSBTAP00000005062 | Pex2_Pex12 domain-containing protein. | Peroxisomal biogenesis factor 2. | 0.993 |
PEX10 | PEX3 | ENSBTAP00000067889 | ENSBTAP00000002294 | Pex2_Pex12 domain-containing protein. | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (By similarity). | 0.797 |
PEX10 | PEX5 | ENSBTAP00000067889 | ENSBTAP00000070766 | Pex2_Pex12 domain-containing protein. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.977 |
PEX10 | PEX6 | ENSBTAP00000067889 | ENSBTAP00000007275 | Pex2_Pex12 domain-containing protein. | Peroxisomal biogenesis factor 6. | 0.993 |
PEX10 | PEX7 | ENSBTAP00000067889 | ENSBTAP00000022338 | Pex2_Pex12 domain-containing protein. | Peroxisomal biogenesis factor 7. | 0.980 |
PEX12 | PEX10 | ENSBTAP00000026285 | ENSBTAP00000067889 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Pex2_Pex12 domain-containing protein. | 0.999 |
PEX12 | PEX13 | ENSBTAP00000026285 | ENSBTAP00000006917 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). | 0.995 |
PEX12 | PEX14 | ENSBTAP00000026285 | ENSBTAP00000058256 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal biogenesis factor 14. | 0.972 |
PEX12 | PEX16 | ENSBTAP00000026285 | ENSBTAP00000072447 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity); Belongs to the peroxin-16 family. | 0.959 |
PEX12 | PEX19 | ENSBTAP00000026285 | ENSBTAP00000009921 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity). | 0.994 |
PEX12 | PEX2 | ENSBTAP00000026285 | ENSBTAP00000005062 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal biogenesis factor 2. | 0.989 |
PEX12 | PEX3 | ENSBTAP00000026285 | ENSBTAP00000002294 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (By similarity). | 0.924 |
PEX12 | PEX5 | ENSBTAP00000026285 | ENSBTAP00000070766 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.987 |
PEX12 | PEX6 | ENSBTAP00000026285 | ENSBTAP00000007275 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal biogenesis factor 6. | 0.990 |
PEX12 | PEX7 | ENSBTAP00000026285 | ENSBTAP00000022338 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. | Peroxisomal biogenesis factor 7. | 0.973 |