STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EPHB3EPH receptor B3. (997 aa)    
Predicted Functional Partners:
EFNB2
Ephrin B2; Belongs to the ephrin family.
   
 0.997
EFNB3
Ephrin RBD domain-containing protein; Belongs to the ephrin family.
   
 0.997
EFNB1
Ephrin-B1; Belongs to the ephrin family.
   
 0.992
ABL1
Tyrosine-protein kinase.
   
0.945
EFNA5
Ephrin-A5; Belongs to the ephrin family.
   
 0.935
RASA1
Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.
   
 0.920
NGEF
Neuronal guanine nucleotide exchange factor.
    
 0.905
EFNA3
Ephrin RBD domain-containing protein; Belongs to the ephrin family.
   
 0.903
EFNA1
Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...]
   
 0.902
EFNA2
EFNA2 protein; Belongs to the ephrin family.
   
 0.876
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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