node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABL1 | EPHB3 | ENSBTAP00000058693 | ENSBTAP00000006988 | Tyrosine-protein kinase. | EPH receptor B3. | 0.945 |
EFNA1 | EFNA2 | ENSBTAP00000004007 | ENSBTAP00000049002 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | EFNA2 protein; Belongs to the ephrin family. | 0.517 |
EFNA1 | EFNA3 | ENSBTAP00000004007 | ENSBTAP00000026958 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.608 |
EFNA1 | EFNA5 | ENSBTAP00000004007 | ENSBTAP00000070454 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin-A5; Belongs to the ephrin family. | 0.644 |
EFNA1 | EFNB1 | ENSBTAP00000004007 | ENSBTAP00000020985 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin-B1; Belongs to the ephrin family. | 0.679 |
EFNA1 | EFNB2 | ENSBTAP00000004007 | ENSBTAP00000035226 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin B2; Belongs to the ephrin family. | 0.680 |
EFNA1 | EFNB3 | ENSBTAP00000004007 | ENSBTAP00000060225 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.674 |
EFNA1 | EPHB3 | ENSBTAP00000004007 | ENSBTAP00000006988 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | EPH receptor B3. | 0.902 |
EFNA1 | NGEF | ENSBTAP00000004007 | ENSBTAP00000011773 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Neuronal guanine nucleotide exchange factor. | 0.527 |
EFNA1 | RASA1 | ENSBTAP00000004007 | ENSBTAP00000012583 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. | 0.919 |
EFNA2 | EFNA1 | ENSBTAP00000049002 | ENSBTAP00000004007 | EFNA2 protein; Belongs to the ephrin family. | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | 0.517 |
EFNA2 | EFNA3 | ENSBTAP00000049002 | ENSBTAP00000026958 | EFNA2 protein; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.447 |
EFNA2 | EFNA5 | ENSBTAP00000049002 | ENSBTAP00000070454 | EFNA2 protein; Belongs to the ephrin family. | Ephrin-A5; Belongs to the ephrin family. | 0.556 |
EFNA2 | EFNB1 | ENSBTAP00000049002 | ENSBTAP00000020985 | EFNA2 protein; Belongs to the ephrin family. | Ephrin-B1; Belongs to the ephrin family. | 0.679 |
EFNA2 | EFNB2 | ENSBTAP00000049002 | ENSBTAP00000035226 | EFNA2 protein; Belongs to the ephrin family. | Ephrin B2; Belongs to the ephrin family. | 0.673 |
EFNA2 | EFNB3 | ENSBTAP00000049002 | ENSBTAP00000060225 | EFNA2 protein; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.672 |
EFNA2 | EPHB3 | ENSBTAP00000049002 | ENSBTAP00000006988 | EFNA2 protein; Belongs to the ephrin family. | EPH receptor B3. | 0.876 |
EFNA2 | NGEF | ENSBTAP00000049002 | ENSBTAP00000011773 | EFNA2 protein; Belongs to the ephrin family. | Neuronal guanine nucleotide exchange factor. | 0.463 |
EFNA2 | RASA1 | ENSBTAP00000049002 | ENSBTAP00000012583 | EFNA2 protein; Belongs to the ephrin family. | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. | 0.907 |
EFNA3 | EFNA1 | ENSBTAP00000026958 | ENSBTAP00000004007 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | 0.608 |