node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD44 | EGFR | ENSBTAP00000048925 | ENSBTAP00000070620 | CD44 antigen. | Receptor protein-tyrosine kinase. | 0.983 |
CD44 | FGF2 | ENSBTAP00000048925 | ENSBTAP00000007477 | CD44 antigen. | Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. | 0.939 |
CD44 | FGFR1 | ENSBTAP00000048925 | ENSBTAP00000058842 | CD44 antigen. | Fibroblast growth factor receptor. | 0.512 |
CD44 | FGFR2 | ENSBTAP00000048925 | ENSBTAP00000059738 | CD44 antigen. | Fibroblast growth factor receptor. | 0.503 |
CD44 | FGFR3 | ENSBTAP00000048925 | ENSBTAP00000073540 | CD44 antigen. | Fibroblast growth factor receptor. | 0.411 |
CD44 | GPC1 | ENSBTAP00000048925 | ENSBTAP00000060932 | CD44 antigen. | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | 0.534 |
CD44 | PDGFRA | ENSBTAP00000048925 | ENSBTAP00000068814 | CD44 antigen. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.648 |
CD44 | TGFB1 | ENSBTAP00000048925 | ENSBTAP00000064484 | CD44 antigen. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.794 |
EGFR | CD44 | ENSBTAP00000070620 | ENSBTAP00000048925 | Receptor protein-tyrosine kinase. | CD44 antigen. | 0.983 |
EGFR | FGF2 | ENSBTAP00000070620 | ENSBTAP00000007477 | Receptor protein-tyrosine kinase. | Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. | 0.947 |
EGFR | FGFR1 | ENSBTAP00000070620 | ENSBTAP00000058842 | Receptor protein-tyrosine kinase. | Fibroblast growth factor receptor. | 0.451 |
EGFR | FGFR2 | ENSBTAP00000070620 | ENSBTAP00000059738 | Receptor protein-tyrosine kinase. | Fibroblast growth factor receptor. | 0.632 |
EGFR | FGFR3 | ENSBTAP00000070620 | ENSBTAP00000073540 | Receptor protein-tyrosine kinase. | Fibroblast growth factor receptor. | 0.631 |
EGFR | GPC1 | ENSBTAP00000070620 | ENSBTAP00000060932 | Receptor protein-tyrosine kinase. | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | 0.489 |
EGFR | PDGFRA | ENSBTAP00000070620 | ENSBTAP00000068814 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.967 |
EGFR | TGFB1 | ENSBTAP00000070620 | ENSBTAP00000064484 | Receptor protein-tyrosine kinase. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.868 |
FGF2 | CD44 | ENSBTAP00000007477 | ENSBTAP00000048925 | Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. | CD44 antigen. | 0.939 |
FGF2 | EGFR | ENSBTAP00000007477 | ENSBTAP00000070620 | Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. | Receptor protein-tyrosine kinase. | 0.947 |
FGF2 | FGFR1 | ENSBTAP00000007477 | ENSBTAP00000058842 | Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.999 |
FGF2 | FGFR2 | ENSBTAP00000007477 | ENSBTAP00000059738 | Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.999 |