node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPC1 | GPC2 | ENSBTAP00000060932 | ENSBTAP00000011679 | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.529 |
GPC1 | GPC4 | ENSBTAP00000060932 | ENSBTAP00000027510 | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.451 |
GPC1 | HPSE | ENSBTAP00000060932 | ENSBTAP00000007550 | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | Heparanase 50 kDa subunit; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inact [...] | 0.641 |
GPC1 | SDC1 | ENSBTAP00000060932 | ENSBTAP00000072853 | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. | 0.986 |
GPC1 | SDC3 | ENSBTAP00000060932 | ENSBTAP00000065590 | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.791 |
GPC1 | SDC4 | ENSBTAP00000060932 | ENSBTAP00000020125 | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.956 |
GPC2 | GPC1 | ENSBTAP00000011679 | ENSBTAP00000060932 | Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | 0.529 |
GPC2 | GPC4 | ENSBTAP00000011679 | ENSBTAP00000027510 | Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.469 |
GPC2 | HPSE | ENSBTAP00000011679 | ENSBTAP00000007550 | Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Heparanase 50 kDa subunit; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inact [...] | 0.630 |
GPC2 | SDC1 | ENSBTAP00000011679 | ENSBTAP00000072853 | Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. | 0.739 |
GPC2 | SDC3 | ENSBTAP00000011679 | ENSBTAP00000065590 | Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.808 |
GPC2 | SDC4 | ENSBTAP00000011679 | ENSBTAP00000020125 | Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.690 |
GPC4 | GPC1 | ENSBTAP00000027510 | ENSBTAP00000060932 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | 0.451 |
GPC4 | GPC2 | ENSBTAP00000027510 | ENSBTAP00000011679 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.469 |
GPC4 | HPSE | ENSBTAP00000027510 | ENSBTAP00000007550 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Heparanase 50 kDa subunit; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inact [...] | 0.563 |
GPC4 | SDC1 | ENSBTAP00000027510 | ENSBTAP00000072853 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. | 0.662 |
GPC4 | SDC3 | ENSBTAP00000027510 | ENSBTAP00000065590 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.794 |
GPC4 | SDC4 | ENSBTAP00000027510 | ENSBTAP00000020125 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.672 |
HPSE | GPC1 | ENSBTAP00000007550 | ENSBTAP00000060932 | Heparanase 50 kDa subunit; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inact [...] | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | 0.641 |
HPSE | GPC2 | ENSBTAP00000007550 | ENSBTAP00000011679 | Heparanase 50 kDa subunit; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inact [...] | Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.630 |