node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFF1 | AFF4 | ENSBTAP00000069534 | ENSBTAP00000012480 | AF4/FMR2 family member 1. | AF4/FMR2 family member 4. | 0.961 |
AFF1 | BRD4 | ENSBTAP00000069534 | ENSBTAP00000070106 | AF4/FMR2 family member 1. | Bromodomain containing 4. | 0.639 |
AFF1 | CCNT1 | ENSBTAP00000069534 | ENSBTAP00000007703 | AF4/FMR2 family member 1. | Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). | 0.968 |
AFF1 | CDK12 | ENSBTAP00000069534 | ENSBTAP00000002005 | AF4/FMR2 family member 1. | Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading [...] | 0.647 |
AFF1 | CDK13 | ENSBTAP00000069534 | ENSBTAP00000002003 | AF4/FMR2 family member 1. | Cyclin-dependent kinase 13; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.649 |
AFF1 | CDK9 | ENSBTAP00000069534 | ENSBTAP00000006162 | AF4/FMR2 family member 1. | Cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELF. Regulates cytoki [...] | 0.967 |
AFF1 | HEXIM1 | ENSBTAP00000069534 | ENSBTAP00000007955 | AF4/FMR2 family member 1. | Protein HEXIM1; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA- dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP- RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response [...] | 0.726 |
AFF1 | LARP7 | ENSBTAP00000069534 | ENSBTAP00000061840 | AF4/FMR2 family member 1. | La ribonucleoprotein domain family member 7. | 0.680 |
AFF4 | AFF1 | ENSBTAP00000012480 | ENSBTAP00000069534 | AF4/FMR2 family member 4. | AF4/FMR2 family member 1. | 0.961 |
AFF4 | BRD4 | ENSBTAP00000012480 | ENSBTAP00000070106 | AF4/FMR2 family member 4. | Bromodomain containing 4. | 0.642 |
AFF4 | CCNT1 | ENSBTAP00000012480 | ENSBTAP00000007703 | AF4/FMR2 family member 4. | Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). | 0.998 |
AFF4 | CDK12 | ENSBTAP00000012480 | ENSBTAP00000002005 | AF4/FMR2 family member 4. | Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading [...] | 0.734 |
AFF4 | CDK13 | ENSBTAP00000012480 | ENSBTAP00000002003 | AF4/FMR2 family member 4. | Cyclin-dependent kinase 13; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.622 |
AFF4 | CDK9 | ENSBTAP00000012480 | ENSBTAP00000006162 | AF4/FMR2 family member 4. | Cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELF. Regulates cytoki [...] | 0.995 |
AFF4 | HEXIM1 | ENSBTAP00000012480 | ENSBTAP00000007955 | AF4/FMR2 family member 4. | Protein HEXIM1; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA- dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP- RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response [...] | 0.820 |
AFF4 | LARP7 | ENSBTAP00000012480 | ENSBTAP00000061840 | AF4/FMR2 family member 4. | La ribonucleoprotein domain family member 7. | 0.749 |
BRD4 | AFF1 | ENSBTAP00000070106 | ENSBTAP00000069534 | Bromodomain containing 4. | AF4/FMR2 family member 1. | 0.639 |
BRD4 | AFF4 | ENSBTAP00000070106 | ENSBTAP00000012480 | Bromodomain containing 4. | AF4/FMR2 family member 4. | 0.642 |
BRD4 | CCNT1 | ENSBTAP00000070106 | ENSBTAP00000007703 | Bromodomain containing 4. | Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). | 0.984 |
BRD4 | CDK12 | ENSBTAP00000070106 | ENSBTAP00000002005 | Bromodomain containing 4. | Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading [...] | 0.478 |