STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SH3GL1Endophilin-A2; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Belongs to the endophilin family. (368 aa)    
Predicted Functional Partners:
SH3GL2
SH3 domain containing GRB2 like 2, endophilin A1.
  
 
0.969
SH3GL3
SH3 domain containing GRB2 like 3, endophilin A3.
  
 
0.966
CBL
Cbl proto-oncogene.
    
 0.902
SYNJ1
Synaptojanin-1; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2. Belongs to the synaptojanin family.
    
 
 0.876
SYNJ2
Synaptojanin 2.
    
 
 0.854
SH3KBP1
SH3 domain containing kinase binding protein 1.
   
0.853
EPS15
Epidermal growth factor receptor pathway substrate 15.
     
 0.809
CBLB
Cbl proto-oncogene B.
    
 0.807
CBLC
Cbl proto-oncogene C.
    
  0.805
CLTC
Clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch- TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Belongs to the clathrin heavy chain [...]
     
 0.794
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.