node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B4GALT7 | EXT1 | ENSBTAP00000035533 | ENSBTAP00000008154 | Beta-1,4-galactosyltransferase 7. | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | 0.739 |
B4GALT7 | EXT2 | ENSBTAP00000035533 | ENSBTAP00000026177 | Beta-1,4-galactosyltransferase 7. | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | 0.732 |
B4GALT7 | EXTL2 | ENSBTAP00000035533 | ENSBTAP00000025321 | Beta-1,4-galactosyltransferase 7. | Exostosin like glycosyltransferase 2. | 0.527 |
B4GALT7 | GLCE | ENSBTAP00000035533 | ENSBTAP00000001844 | Beta-1,4-galactosyltransferase 7. | D-glucuronyl C5-epimerase; Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins; Belongs to the D-glucuronyl C5-epimerase family. | 0.693 |
B4GALT7 | GPC1 | ENSBTAP00000035533 | ENSBTAP00000060932 | Beta-1,4-galactosyltransferase 7. | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | 0.505 |
B4GALT7 | HS2ST1 | ENSBTAP00000035533 | ENSBTAP00000064686 | Beta-1,4-galactosyltransferase 7. | Uncharacterized protein. | 0.803 |
B4GALT7 | HS6ST1 | ENSBTAP00000035533 | ENSBTAP00000058461 | Beta-1,4-galactosyltransferase 7. | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.614 |
B4GALT7 | NDST1 | ENSBTAP00000035533 | ENSBTAP00000016824 | Beta-1,4-galactosyltransferase 7. | N-deacetylase and N-sulfotransferase 1. | 0.729 |
B4GALT7 | SLC35B2 | ENSBTAP00000035533 | ENSBTAP00000010620 | Beta-1,4-galactosyltransferase 7. | Solute carrier family 35, member B2. | 0.825 |
EXT1 | B4GALT7 | ENSBTAP00000008154 | ENSBTAP00000035533 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Beta-1,4-galactosyltransferase 7. | 0.739 |
EXT1 | EXT2 | ENSBTAP00000008154 | ENSBTAP00000026177 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | 0.998 |
EXT1 | EXTL2 | ENSBTAP00000008154 | ENSBTAP00000025321 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Exostosin like glycosyltransferase 2. | 0.787 |
EXT1 | GLCE | ENSBTAP00000008154 | ENSBTAP00000001844 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | D-glucuronyl C5-epimerase; Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins; Belongs to the D-glucuronyl C5-epimerase family. | 0.822 |
EXT1 | GPC1 | ENSBTAP00000008154 | ENSBTAP00000060932 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting [...] | 0.757 |
EXT1 | HS2ST1 | ENSBTAP00000008154 | ENSBTAP00000064686 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Uncharacterized protein. | 0.832 |
EXT1 | HS6ST1 | ENSBTAP00000008154 | ENSBTAP00000058461 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.735 |
EXT1 | NDST1 | ENSBTAP00000008154 | ENSBTAP00000016824 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | N-deacetylase and N-sulfotransferase 1. | 0.859 |
EXT1 | NDST2 | ENSBTAP00000008154 | ENSBTAP00000016827 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | 0.820 |
EXT1 | SLC35B2 | ENSBTAP00000008154 | ENSBTAP00000010620 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). | Solute carrier family 35, member B2. | 0.730 |
EXT2 | B4GALT7 | ENSBTAP00000026177 | ENSBTAP00000035533 | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. | Beta-1,4-galactosyltransferase 7. | 0.732 |