STRINGSTRING
EXT1 protein (Bos taurus) - STRING interaction network
"EXT1" - Exostosin-1 in Bos taurus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EXT1Exostosin-1 ; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity) (746 aa)    
Predicted Functional Partners:
GPC1
Glypican-1 Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and [...] (559 aa)
     
 
  0.949
GPC4
Glypican-4 precursor ; Cell surface proteoglycan that bears heparan sulfate (505 aa)
     
 
  0.943
GPC2
Glypican-2 precursor ; Cell surface proteoglycan that bears heparan sulfate (508 aa)
     
 
  0.943
GPC6
Glypican-6 precursor ; Cell surface proteoglycan that bears heparan sulfate (154 aa)
     
 
  0.939
GPC3
Glypican-3 precursor ; Cell surface proteoglycan that bears heparan sulfate (580 aa)
     
 
  0.930
GPC5
Glypican-5 precursor ; Cell surface proteoglycan that bears heparan sulfate (595 aa)
     
 
  0.930
SDC2
Syndecan-2 ; Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity) (202 aa)
     
 
  0.920
HSPG2
Uncharacterized protein (4374 aa)
         
  0.908
SDC1
Syndecan-1 ; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (311 aa)
     
 
  0.907
SDC4
Syndecan ; Cell surface proteoglycan (201 aa)
         
  0.906
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae, Bovidae sp. Adi Nefas, Bovinae, Pecora, Ruminantia, bovine, cattle, cow, domestic cattle, domestic cow, oxen, cattle
Server load: low (14%) [HD]