node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP1 | COL1A1 | ENSBTAP00000001218 | ENSBTAP00000017420 | Metalloendopeptidase. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.746 |
BMP1 | LOX | ENSBTAP00000001218 | ENSBTAP00000068980 | Metalloendopeptidase. | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. | 0.848 |
BMP1 | LOXL1 | ENSBTAP00000001218 | ENSBTAP00000011978 | Metalloendopeptidase. | Lysyl oxidase homolog 1; Active on elastin and collagen substrates. | 0.744 |
BMP1 | LOXL2 | ENSBTAP00000001218 | ENSBTAP00000008159 | Metalloendopeptidase. | Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] | 0.691 |
BMP1 | PLOD2 | ENSBTAP00000001218 | ENSBTAP00000031895 | Metalloendopeptidase. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. | 0.502 |
COL1A1 | BMP1 | ENSBTAP00000017420 | ENSBTAP00000001218 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Metalloendopeptidase. | 0.746 |
COL1A1 | COL4A1 | ENSBTAP00000017420 | ENSBTAP00000035211 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. | 0.670 |
COL1A1 | ELN | ENSBTAP00000017420 | ENSBTAP00000069595 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity); Belongs to the elastin family. | 0.809 |
COL1A1 | FBLN5 | ENSBTAP00000017420 | ENSBTAP00000063953 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. | 0.569 |
COL1A1 | LOX | ENSBTAP00000017420 | ENSBTAP00000068980 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. | 0.796 |
COL1A1 | LOXL1 | ENSBTAP00000017420 | ENSBTAP00000011978 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Lysyl oxidase homolog 1; Active on elastin and collagen substrates. | 0.631 |
COL1A1 | LOXL2 | ENSBTAP00000017420 | ENSBTAP00000008159 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] | 0.659 |
COL1A1 | PLOD2 | ENSBTAP00000017420 | ENSBTAP00000031895 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. | 0.817 |
COL1A1 | SNAI1 | ENSBTAP00000017420 | ENSBTAP00000058415 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Snail family transcriptional repressor 1. | 0.571 |
COL4A1 | COL1A1 | ENSBTAP00000035211 | ENSBTAP00000017420 | Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.670 |
COL4A1 | ELN | ENSBTAP00000035211 | ENSBTAP00000069595 | Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity); Belongs to the elastin family. | 0.459 |
COL4A1 | LOX | ENSBTAP00000035211 | ENSBTAP00000068980 | Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. | 0.608 |
COL4A1 | LOXL2 | ENSBTAP00000035211 | ENSBTAP00000008159 | Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. | Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] | 0.625 |
COL4A1 | PLOD2 | ENSBTAP00000035211 | ENSBTAP00000031895 | Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. | 0.703 |
ELN | COL1A1 | ENSBTAP00000069595 | ENSBTAP00000017420 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity); Belongs to the elastin family. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.809 |