node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AURKA | NEDD9 | ENSBTAP00000042073 | ENSBTAP00000055362 | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation [...] | Neural precursor cell expressed, developmentally down-regulated 9. | 0.675 |
BCAR3 | NEDD9 | ENSBTAP00000068264 | ENSBTAP00000055362 | Breast cancer anti-estrogen resistance protein 3 homolog; Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and [...] | Neural precursor cell expressed, developmentally down-regulated 9. | 0.728 |
BCAR3 | SRC | ENSBTAP00000068264 | ENSBTAP00000011767 | Breast cancer anti-estrogen resistance protein 3 homolog; Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and [...] | Tyrosine-protein kinase. | 0.431 |
CRK | DOCK3 | ENSBTAP00000007443 | ENSBTAP00000073482 | CRK proto-oncogene, adaptor protein. | Dedicator of cytokinesis 3; Belongs to the DOCK family. | 0.615 |
CRK | NEDD9 | ENSBTAP00000007443 | ENSBTAP00000055362 | CRK proto-oncogene, adaptor protein. | Neural precursor cell expressed, developmentally down-regulated 9. | 0.742 |
CRK | PTK2 | ENSBTAP00000007443 | ENSBTAP00000065036 | CRK proto-oncogene, adaptor protein. | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.976 |
CRK | PXN | ENSBTAP00000007443 | ENSBTAP00000024101 | CRK proto-oncogene, adaptor protein. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.982 |
CRK | SRC | ENSBTAP00000007443 | ENSBTAP00000011767 | CRK proto-oncogene, adaptor protein. | Tyrosine-protein kinase. | 0.990 |
CRK | TGFB1I1 | ENSBTAP00000007443 | ENSBTAP00000003094 | CRK proto-oncogene, adaptor protein. | Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. [...] | 0.530 |
DOCK3 | CRK | ENSBTAP00000073482 | ENSBTAP00000007443 | Dedicator of cytokinesis 3; Belongs to the DOCK family. | CRK proto-oncogene, adaptor protein. | 0.615 |
DOCK3 | NEDD9 | ENSBTAP00000073482 | ENSBTAP00000055362 | Dedicator of cytokinesis 3; Belongs to the DOCK family. | Neural precursor cell expressed, developmentally down-regulated 9. | 0.804 |
NEDD9 | AURKA | ENSBTAP00000055362 | ENSBTAP00000042073 | Neural precursor cell expressed, developmentally down-regulated 9. | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation [...] | 0.675 |
NEDD9 | BCAR3 | ENSBTAP00000055362 | ENSBTAP00000068264 | Neural precursor cell expressed, developmentally down-regulated 9. | Breast cancer anti-estrogen resistance protein 3 homolog; Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and [...] | 0.728 |
NEDD9 | CRK | ENSBTAP00000055362 | ENSBTAP00000007443 | Neural precursor cell expressed, developmentally down-regulated 9. | CRK proto-oncogene, adaptor protein. | 0.742 |
NEDD9 | DOCK3 | ENSBTAP00000055362 | ENSBTAP00000073482 | Neural precursor cell expressed, developmentally down-regulated 9. | Dedicator of cytokinesis 3; Belongs to the DOCK family. | 0.804 |
NEDD9 | PTK2 | ENSBTAP00000055362 | ENSBTAP00000065036 | Neural precursor cell expressed, developmentally down-regulated 9. | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.679 |
NEDD9 | PXN | ENSBTAP00000055362 | ENSBTAP00000024101 | Neural precursor cell expressed, developmentally down-regulated 9. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.631 |
NEDD9 | SH2D3C | ENSBTAP00000055362 | ENSBTAP00000020433 | Neural precursor cell expressed, developmentally down-regulated 9. | SH2 domain containing 3C. | 0.672 |
NEDD9 | SH3BP5L | ENSBTAP00000055362 | ENSBTAP00000003422 | Neural precursor cell expressed, developmentally down-regulated 9. | SH3 domain-binding protein 5-like; Functions as guanine nucleotide exchange factor (GEF) for RAB11A. | 0.603 |
NEDD9 | SRC | ENSBTAP00000055362 | ENSBTAP00000011767 | Neural precursor cell expressed, developmentally down-regulated 9. | Tyrosine-protein kinase. | 0.767 |