STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHMP4ACharged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (222 aa)    
Predicted Functional Partners:
PDCD6IP
Programmed cell death 6 interacting protein.
    
 0.983
CHMP7
Charged multivesicular body protein 7.
    
0.916
CHMP4B
Charged multivesicular body protein 4B.
  
 
0.914
CHMP4C
Charged multivesicular body protein 4C.
  
 
0.911
MLKL
Mixed lineage kinase domain like pseudokinase.
     
 0.903
SLC5A8
Sodium-dependent monocarboxylate cotransporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
   
    0.797
PTPN23
Protein tyrosine phosphatase non-receptor type 23.
    
 
 0.768
VPS37A
Vacuolar protein sorting 37 homolog A (S. cerevisiae).
     
 0.764
MVB12A
Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity); Belongs to the MVB12 family.
     
 0.754
VPS4A
Uncharacterized protein; Belongs to the AAA ATPase family.
   
 0.745
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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