node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHMP4A | CHMP4B | ENSBTAP00000008352 | ENSBTAP00000017812 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Charged multivesicular body protein 4B. | 0.914 |
CHMP4A | CHMP4C | ENSBTAP00000008352 | ENSBTAP00000006291 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Charged multivesicular body protein 4C. | 0.911 |
CHMP4A | CHMP7 | ENSBTAP00000008352 | ENSBTAP00000017987 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Charged multivesicular body protein 7. | 0.916 |
CHMP4A | MLKL | ENSBTAP00000008352 | ENSBTAP00000056914 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Mixed lineage kinase domain like pseudokinase. | 0.903 |
CHMP4A | MVB12A | ENSBTAP00000008352 | ENSBTAP00000005111 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity); Belongs to the MVB12 family. | 0.754 |
CHMP4A | PDCD6IP | ENSBTAP00000008352 | ENSBTAP00000023165 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Programmed cell death 6 interacting protein. | 0.983 |
CHMP4A | PTPN23 | ENSBTAP00000008352 | ENSBTAP00000003600 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Protein tyrosine phosphatase non-receptor type 23. | 0.768 |
CHMP4A | SLC5A8 | ENSBTAP00000008352 | ENSBTAP00000015315 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Sodium-dependent monocarboxylate cotransporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.797 |
CHMP4A | VPS37A | ENSBTAP00000008352 | ENSBTAP00000013675 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Vacuolar protein sorting 37 homolog A (S. cerevisiae). | 0.764 |
CHMP4A | VPS4A | ENSBTAP00000008352 | ENSBTAP00000055660 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | Uncharacterized protein; Belongs to the AAA ATPase family. | 0.745 |
CHMP4B | CHMP4A | ENSBTAP00000017812 | ENSBTAP00000008352 | Charged multivesicular body protein 4B. | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.914 |
CHMP4B | CHMP4C | ENSBTAP00000017812 | ENSBTAP00000006291 | Charged multivesicular body protein 4B. | Charged multivesicular body protein 4C. | 0.908 |
CHMP4B | CHMP7 | ENSBTAP00000017812 | ENSBTAP00000017987 | Charged multivesicular body protein 4B. | Charged multivesicular body protein 7. | 0.953 |
CHMP4B | MLKL | ENSBTAP00000017812 | ENSBTAP00000056914 | Charged multivesicular body protein 4B. | Mixed lineage kinase domain like pseudokinase. | 0.915 |
CHMP4B | MVB12A | ENSBTAP00000017812 | ENSBTAP00000005111 | Charged multivesicular body protein 4B. | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity); Belongs to the MVB12 family. | 0.549 |
CHMP4B | PDCD6IP | ENSBTAP00000017812 | ENSBTAP00000023165 | Charged multivesicular body protein 4B. | Programmed cell death 6 interacting protein. | 0.981 |
CHMP4B | PTPN23 | ENSBTAP00000017812 | ENSBTAP00000003600 | Charged multivesicular body protein 4B. | Protein tyrosine phosphatase non-receptor type 23. | 0.858 |
CHMP4B | VPS37A | ENSBTAP00000017812 | ENSBTAP00000013675 | Charged multivesicular body protein 4B. | Vacuolar protein sorting 37 homolog A (S. cerevisiae). | 0.604 |
CHMP4B | VPS4A | ENSBTAP00000017812 | ENSBTAP00000055660 | Charged multivesicular body protein 4B. | Uncharacterized protein; Belongs to the AAA ATPase family. | 0.925 |
CHMP4C | CHMP4A | ENSBTAP00000006291 | ENSBTAP00000008352 | Charged multivesicular body protein 4C. | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.911 |