node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DKC1 | ENSBTAP00000062724 | ENSBTAP00000017339 | ENSBTAP00000062724 | Dyskerin pseudouridine synthase 1. | Uncharacterized protein. | 0.957 |
DKC1 | FBL | ENSBTAP00000017339 | ENSBTAP00000003340 | Dyskerin pseudouridine synthase 1. | Fibrillarin. | 0.994 |
DKC1 | GAR1 | ENSBTAP00000017339 | ENSBTAP00000063824 | Dyskerin pseudouridine synthase 1. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.999 |
DKC1 | MRTO4 | ENSBTAP00000017339 | ENSBTAP00000015861 | Dyskerin pseudouridine synthase 1. | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. | 0.848 |
DKC1 | NHP2 | ENSBTAP00000017339 | ENSBTAP00000008363 | Dyskerin pseudouridine synthase 1. | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | 0.999 |
DKC1 | NOP10 | ENSBTAP00000017339 | ENSBTAP00000036040 | Dyskerin pseudouridine synthase 1. | NOP10 ribonucleoprotein homolog (Yeast). | 0.999 |
DKC1 | NOP56 | ENSBTAP00000017339 | ENSBTAP00000025042 | Dyskerin pseudouridine synthase 1. | Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). | 0.999 |
DKC1 | NOP58 | ENSBTAP00000017339 | ENSBTAP00000061048 | Dyskerin pseudouridine synthase 1. | NOP58 ribonucleoprotein. | 0.997 |
DKC1 | TERT | ENSBTAP00000017339 | ENSBTAP00000016685 | Dyskerin pseudouridine synthase 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.987 |
DKC1 | WRAP53 | ENSBTAP00000017339 | ENSBTAP00000057850 | Dyskerin pseudouridine synthase 1. | Telomerase Cajal body protein 1; RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically b [...] | 0.997 |
ENSBTAP00000062724 | DKC1 | ENSBTAP00000062724 | ENSBTAP00000017339 | Uncharacterized protein. | Dyskerin pseudouridine synthase 1. | 0.957 |
ENSBTAP00000062724 | FBL | ENSBTAP00000062724 | ENSBTAP00000003340 | Uncharacterized protein. | Fibrillarin. | 0.734 |
ENSBTAP00000062724 | GAR1 | ENSBTAP00000062724 | ENSBTAP00000063824 | Uncharacterized protein. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.964 |
ENSBTAP00000062724 | MRTO4 | ENSBTAP00000062724 | ENSBTAP00000015861 | Uncharacterized protein. | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. | 0.460 |
ENSBTAP00000062724 | NHP2 | ENSBTAP00000062724 | ENSBTAP00000008363 | Uncharacterized protein. | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | 0.983 |
ENSBTAP00000062724 | NOP10 | ENSBTAP00000062724 | ENSBTAP00000036040 | Uncharacterized protein. | NOP10 ribonucleoprotein homolog (Yeast). | 0.551 |
ENSBTAP00000062724 | NOP56 | ENSBTAP00000062724 | ENSBTAP00000025042 | Uncharacterized protein. | Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). | 0.804 |
ENSBTAP00000062724 | NOP58 | ENSBTAP00000062724 | ENSBTAP00000061048 | Uncharacterized protein. | NOP58 ribonucleoprotein. | 0.756 |
ENSBTAP00000062724 | TERT | ENSBTAP00000062724 | ENSBTAP00000016685 | Uncharacterized protein. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.675 |
ENSBTAP00000062724 | WRAP53 | ENSBTAP00000062724 | ENSBTAP00000057850 | Uncharacterized protein. | Telomerase Cajal body protein 1; RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically b [...] | 0.837 |