| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MB | MYH7 | ENSBTAP00000007014 | ENSBTAP00000053217 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.946 |
| MB | MYL1 | ENSBTAP00000007014 | ENSBTAP00000049636 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.843 |
| MB | MYL2 | ENSBTAP00000007014 | ENSBTAP00000066211 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.546 |
| MB | MYOZ1 | ENSBTAP00000007014 | ENSBTAP00000051138 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). | 0.572 |
| MB | TNNC2 | ENSBTAP00000007014 | ENSBTAP00000055007 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Troponin C2, fast skeletal type. | 0.536 |
| MB | TNNI1 | ENSBTAP00000007014 | ENSBTAP00000054671 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Troponin I1, slow skeletal type. | 0.617 |
| MB | TNNI2 | ENSBTAP00000007014 | ENSBTAP00000014452 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Troponin I2, fast skeletal type. | 0.524 |
| MB | TNNT1 | ENSBTAP00000007014 | ENSBTAP00000073026 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.942 |
| MYH7 | MB | ENSBTAP00000053217 | ENSBTAP00000007014 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | 0.946 |
| MYH7 | MYL1 | ENSBTAP00000053217 | ENSBTAP00000049636 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.989 |
| MYH7 | MYL2 | ENSBTAP00000053217 | ENSBTAP00000066211 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.978 |
| MYH7 | MYOZ1 | ENSBTAP00000053217 | ENSBTAP00000051138 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). | 0.689 |
| MYH7 | TNNC2 | ENSBTAP00000053217 | ENSBTAP00000055007 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Troponin C2, fast skeletal type. | 0.734 |
| MYH7 | TNNI1 | ENSBTAP00000053217 | ENSBTAP00000054671 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Troponin I1, slow skeletal type. | 0.855 |
| MYH7 | TNNI2 | ENSBTAP00000053217 | ENSBTAP00000014452 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Troponin I2, fast skeletal type. | 0.824 |
| MYH7 | TNNT1 | ENSBTAP00000053217 | ENSBTAP00000073026 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.931 |
| MYH7 | TPM2 | ENSBTAP00000053217 | ENSBTAP00000043502 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization; Belongs to the tropomyosin family. | 0.678 |
| MYH7 | TPM3 | ENSBTAP00000053217 | ENSBTAP00000013077 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. | 0.673 |
| MYL1 | MB | ENSBTAP00000049636 | ENSBTAP00000007014 | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. | 0.843 |
| MYL1 | MYH7 | ENSBTAP00000049636 | ENSBTAP00000053217 | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.989 |
STRING v12.5 is now available!
