node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPSCR1 | NPLOC4 | ENSBTAP00000054549 | ENSBTAP00000040249 | UBX domain-containing protein. | NPL4 homolog, ubiquitin recognition factor. | 0.973 |
ASPSCR1 | NSFL1C | ENSBTAP00000054549 | ENSBTAP00000008580 | UBX domain-containing protein. | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. | 0.974 |
ASPSCR1 | UBXN1 | ENSBTAP00000054549 | ENSBTAP00000013845 | UBX domain-containing protein. | UBX domain-containing protein 1; Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'- linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1- BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity). | 0.480 |
ASPSCR1 | UBXN10 | ENSBTAP00000054549 | ENSBTAP00000052187 | UBX domain-containing protein. | UBX domain protein 10. | 0.951 |
ASPSCR1 | UBXN2A | ENSBTAP00000054549 | ENSBTAP00000002634 | UBX domain-containing protein. | UBX domain protein 2A. | 0.971 |
ASPSCR1 | UBXN6 | ENSBTAP00000054549 | ENSBTAP00000010767 | UBX domain-containing protein. | UBX domain-containing protein 6; May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. | 0.966 |
ASPSCR1 | UBXN7 | ENSBTAP00000054549 | ENSBTAP00000009970 | UBX domain-containing protein. | UBX domain-containing protein 7. | 0.981 |
ASPSCR1 | UFD1 | ENSBTAP00000054549 | ENSBTAP00000064002 | UBX domain-containing protein. | Ubiquitin recognition factor in ER associated degradation 1. | 0.447 |
ASPSCR1 | VCP | ENSBTAP00000054549 | ENSBTAP00000019970 | UBX domain-containing protein. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] | 0.961 |
NPLOC4 | ASPSCR1 | ENSBTAP00000040249 | ENSBTAP00000054549 | NPL4 homolog, ubiquitin recognition factor. | UBX domain-containing protein. | 0.973 |
NPLOC4 | NSFL1C | ENSBTAP00000040249 | ENSBTAP00000008580 | NPL4 homolog, ubiquitin recognition factor. | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. | 0.971 |
NPLOC4 | UBXN1 | ENSBTAP00000040249 | ENSBTAP00000013845 | NPL4 homolog, ubiquitin recognition factor. | UBX domain-containing protein 1; Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'- linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1- BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity). | 0.776 |
NPLOC4 | UBXN10 | ENSBTAP00000040249 | ENSBTAP00000052187 | NPL4 homolog, ubiquitin recognition factor. | UBX domain protein 10. | 0.954 |
NPLOC4 | UBXN2A | ENSBTAP00000040249 | ENSBTAP00000002634 | NPL4 homolog, ubiquitin recognition factor. | UBX domain protein 2A. | 0.671 |
NPLOC4 | UBXN6 | ENSBTAP00000040249 | ENSBTAP00000010767 | NPL4 homolog, ubiquitin recognition factor. | UBX domain-containing protein 6; May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. | 0.866 |
NPLOC4 | UBXN7 | ENSBTAP00000040249 | ENSBTAP00000009970 | NPL4 homolog, ubiquitin recognition factor. | UBX domain-containing protein 7. | 0.993 |
NPLOC4 | UFD1 | ENSBTAP00000040249 | ENSBTAP00000064002 | NPL4 homolog, ubiquitin recognition factor. | Ubiquitin recognition factor in ER associated degradation 1. | 0.999 |
NPLOC4 | VCP | ENSBTAP00000040249 | ENSBTAP00000019970 | NPL4 homolog, ubiquitin recognition factor. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] | 0.999 |
NPLOC4 | VCPIP1 | ENSBTAP00000040249 | ENSBTAP00000008802 | NPL4 homolog, ubiquitin recognition factor. | Valosin containing protein interacting protein 1. | 0.955 |
NSFL1C | ASPSCR1 | ENSBTAP00000008580 | ENSBTAP00000054549 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. | UBX domain-containing protein. | 0.974 |