node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNE1 | CCNE2 | ENSBTAP00000006215 | ENSBTAP00000006455 | Cyclin E1; Belongs to the cyclin family. | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily. | 0.948 |
CCNE1 | CCNG1 | ENSBTAP00000006215 | ENSBTAP00000008669 | Cyclin E1; Belongs to the cyclin family. | Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity); Belongs to the cyclin family. Cyclin G subfamily. | 0.628 |
CCNE1 | CCNG2 | ENSBTAP00000006215 | ENSBTAP00000029017 | Cyclin E1; Belongs to the cyclin family. | Cyclin G2; Belongs to the cyclin family. | 0.570 |
CCNE1 | CCNH | ENSBTAP00000006215 | ENSBTAP00000071635 | Cyclin E1; Belongs to the cyclin family. | Cyclin-H; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout t [...] | 0.731 |
CCNE1 | CDKN1A | ENSBTAP00000006215 | ENSBTAP00000011001 | Cyclin E1; Belongs to the cyclin family. | Cyclin dependent kinase inhibitor 1A. | 0.998 |
CCNE1 | MDM2 | ENSBTAP00000006215 | ENSBTAP00000072778 | Cyclin E1; Belongs to the cyclin family. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.511 |
CCNE1 | TP53 | ENSBTAP00000006215 | ENSBTAP00000001420 | Cyclin E1; Belongs to the cyclin family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.714 |
CCNE2 | CCNE1 | ENSBTAP00000006455 | ENSBTAP00000006215 | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily. | Cyclin E1; Belongs to the cyclin family. | 0.948 |
CCNE2 | CCNG1 | ENSBTAP00000006455 | ENSBTAP00000008669 | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily. | Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity); Belongs to the cyclin family. Cyclin G subfamily. | 0.612 |
CCNE2 | CCNG2 | ENSBTAP00000006455 | ENSBTAP00000029017 | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily. | Cyclin G2; Belongs to the cyclin family. | 0.618 |
CCNE2 | CCNH | ENSBTAP00000006455 | ENSBTAP00000071635 | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily. | Cyclin-H; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout t [...] | 0.700 |
CCNE2 | CDKN1A | ENSBTAP00000006455 | ENSBTAP00000011001 | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily. | Cyclin dependent kinase inhibitor 1A. | 0.994 |
CCNE2 | GADD45A | ENSBTAP00000006455 | ENSBTAP00000033363 | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily. | Growth arrest and DNA damage-inducible protein GADD45 alpha; Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). | 0.452 |
CCNE2 | MDM2 | ENSBTAP00000006455 | ENSBTAP00000072778 | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.441 |
CCNE2 | TP53 | ENSBTAP00000006455 | ENSBTAP00000001420 | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.498 |
CCNG1 | CCNE1 | ENSBTAP00000008669 | ENSBTAP00000006215 | Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity); Belongs to the cyclin family. Cyclin G subfamily. | Cyclin E1; Belongs to the cyclin family. | 0.628 |
CCNG1 | CCNE2 | ENSBTAP00000008669 | ENSBTAP00000006455 | Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity); Belongs to the cyclin family. Cyclin G subfamily. | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily. | 0.612 |
CCNG1 | CCNG2 | ENSBTAP00000008669 | ENSBTAP00000029017 | Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity); Belongs to the cyclin family. Cyclin G subfamily. | Cyclin G2; Belongs to the cyclin family. | 0.908 |
CCNG1 | CCNH | ENSBTAP00000008669 | ENSBTAP00000071635 | Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity); Belongs to the cyclin family. Cyclin G subfamily. | Cyclin-H; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout t [...] | 0.615 |
CCNG1 | CDKN1A | ENSBTAP00000008669 | ENSBTAP00000011001 | Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity); Belongs to the cyclin family. Cyclin G subfamily. | Cyclin dependent kinase inhibitor 1A. | 0.650 |