STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MARCHF3E3 ubiquitin-protein ligase MARCHF3; E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. (253 aa)    
Predicted Functional Partners:
MARCHF10
Membrane associated ring-CH-type finger 10.
      
 0.783
MARCHF7
Membrane associated ring-CH-type finger 7.
      
 0.717
LRP2BP
LRP2 binding protein.
      
 0.649
STX6
STX6 protein; Belongs to the syntaxin family.
    
 
 0.621
FBXO28
F-box only protein 28; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
   
    0.615
MARCHF5
E3 ubiquitin-protein ligase MARCHF5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
   
  
 0.608
CNOT2
CCR4-NOT transcription complex subunit 2.
   
 
 0.579
TMEM52
Transmembrane protein 52.
      
 0.578
SLX4IP
Uncharacterized protein.
      
 0.567
ANKRD9
Ankyrin repeat domain 9.
   
 
 0.565
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.