node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC34 | RPS27A | ENSBTAP00000002707 | ENSBTAP00000061054 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-40S ribosomal protein S27a. | 0.798 |
CDC34 | UBA1 | ENSBTAP00000002707 | ENSBTAP00000057326 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | 0.933 |
CDC34 | UBA52 | ENSBTAP00000002707 | ENSBTAP00000010176 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] | 0.869 |
CDC34 | UBA6 | ENSBTAP00000002707 | ENSBTAP00000008985 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin like modifier activating enzyme 6. | 0.876 |
CDC34 | UBA7 | ENSBTAP00000002707 | ENSBTAP00000016365 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin like modifier activating enzyme 7. | 0.830 |
CDC34 | UBE2A | ENSBTAP00000002707 | ENSBTAP00000063161 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. | 0.570 |
CDC34 | UBE2K | ENSBTAP00000002707 | ENSBTAP00000026871 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-conjugating enzyme E2 K; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam [...] | 0.592 |
CDC34 | UBE2N | ENSBTAP00000002707 | ENSBTAP00000067744 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] | 0.560 |
CDC34 | UBE2S | ENSBTAP00000002707 | ENSBTAP00000058650 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] | 0.628 |
CDC34 | UBE2Z | ENSBTAP00000002707 | ENSBTAP00000040996 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin conjugating enzyme E2 Z. | 0.571 |
RPS27A | CDC34 | ENSBTAP00000061054 | ENSBTAP00000002707 | Ubiquitin-40S ribosomal protein S27a. | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. | 0.798 |
RPS27A | UBA1 | ENSBTAP00000061054 | ENSBTAP00000057326 | Ubiquitin-40S ribosomal protein S27a. | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | 0.821 |
RPS27A | UBA52 | ENSBTAP00000061054 | ENSBTAP00000010176 | Ubiquitin-40S ribosomal protein S27a. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] | 0.998 |
RPS27A | UBA6 | ENSBTAP00000061054 | ENSBTAP00000008985 | Ubiquitin-40S ribosomal protein S27a. | Ubiquitin like modifier activating enzyme 6. | 0.921 |
RPS27A | UBA7 | ENSBTAP00000061054 | ENSBTAP00000016365 | Ubiquitin-40S ribosomal protein S27a. | Ubiquitin like modifier activating enzyme 7. | 0.821 |
RPS27A | UBE2A | ENSBTAP00000061054 | ENSBTAP00000063161 | Ubiquitin-40S ribosomal protein S27a. | Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. | 0.791 |
RPS27A | UBE2K | ENSBTAP00000061054 | ENSBTAP00000026871 | Ubiquitin-40S ribosomal protein S27a. | Ubiquitin-conjugating enzyme E2 K; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam [...] | 0.989 |
RPS27A | UBE2N | ENSBTAP00000061054 | ENSBTAP00000067744 | Ubiquitin-40S ribosomal protein S27a. | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] | 0.993 |
RPS27A | UBE2S | ENSBTAP00000061054 | ENSBTAP00000058650 | Ubiquitin-40S ribosomal protein S27a. | Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] | 0.868 |
RPS27A | UBE2Z | ENSBTAP00000061054 | ENSBTAP00000040996 | Ubiquitin-40S ribosomal protein S27a. | Ubiquitin conjugating enzyme E2 Z. | 0.591 |