node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOD1 | AIFM1 | ENSBTAP00000010869 | ENSBTAP00000008987 | Aconitate decarboxylase 1. | Apoptosis inducing factor mitochondria associated 1. | 0.690 |
AIFM1 | ACOD1 | ENSBTAP00000008987 | ENSBTAP00000010869 | Apoptosis inducing factor mitochondria associated 1. | Aconitate decarboxylase 1. | 0.690 |
AIFM1 | BAX | ENSBTAP00000008987 | ENSBTAP00000073472 | Apoptosis inducing factor mitochondria associated 1. | Apoptosis regulator BAX; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production (By similarity). Interacts (via a C-terminal 33 residues) with NOL3 (via CARD domai [...] | 0.920 |
AIFM1 | DAO | ENSBTAP00000008987 | ENSBTAP00000025068 | Apoptosis inducing factor mitochondria associated 1. | D-amino acid oxidase. | 0.690 |
AIFM1 | ENDOG | ENSBTAP00000008987 | ENSBTAP00000016564 | Apoptosis inducing factor mitochondria associated 1. | Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single- stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. | 0.823 |
AIFM1 | F1MNW5_BOVIN | ENSBTAP00000008987 | ENSBTAP00000049897 | Apoptosis inducing factor mitochondria associated 1. | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | 0.843 |
AIFM1 | FDX1 | ENSBTAP00000008987 | ENSBTAP00000015660 | Apoptosis inducing factor mitochondria associated 1. | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. | 0.726 |
AIFM1 | H2AFY | ENSBTAP00000008987 | ENSBTAP00000021436 | Apoptosis inducing factor mitochondria associated 1. | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. | 0.708 |
AIFM1 | LOC613401 | ENSBTAP00000008987 | ENSBTAP00000052127 | Apoptosis inducing factor mitochondria associated 1. | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | 0.843 |
AIFM1 | PIPOX | ENSBTAP00000008987 | ENSBTAP00000010444 | Apoptosis inducing factor mitochondria associated 1. | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. Belongs to the MSOX/MTOX family. | 0.690 |
AIFM1 | PPIA | ENSBTAP00000008987 | ENSBTAP00000015924 | Apoptosis inducing factor mitochondria associated 1. | Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. | 0.853 |
BAX | AIFM1 | ENSBTAP00000073472 | ENSBTAP00000008987 | Apoptosis regulator BAX; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production (By similarity). Interacts (via a C-terminal 33 residues) with NOL3 (via CARD domai [...] | Apoptosis inducing factor mitochondria associated 1. | 0.920 |
DAO | AIFM1 | ENSBTAP00000025068 | ENSBTAP00000008987 | D-amino acid oxidase. | Apoptosis inducing factor mitochondria associated 1. | 0.690 |
DAO | PIPOX | ENSBTAP00000025068 | ENSBTAP00000010444 | D-amino acid oxidase. | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. Belongs to the MSOX/MTOX family. | 0.944 |
ENDOG | AIFM1 | ENSBTAP00000016564 | ENSBTAP00000008987 | Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single- stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. | Apoptosis inducing factor mitochondria associated 1. | 0.823 |
F1MNW5_BOVIN | AIFM1 | ENSBTAP00000049897 | ENSBTAP00000008987 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | Apoptosis inducing factor mitochondria associated 1. | 0.843 |
F1MNW5_BOVIN | H2AFY | ENSBTAP00000049897 | ENSBTAP00000021436 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. | 0.652 |
F1MNW5_BOVIN | LOC613401 | ENSBTAP00000049897 | ENSBTAP00000052127 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | 0.901 |
F1MNW5_BOVIN | PPIA | ENSBTAP00000049897 | ENSBTAP00000015924 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. | 0.901 |
FDX1 | AIFM1 | ENSBTAP00000015660 | ENSBTAP00000008987 | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. | Apoptosis inducing factor mitochondria associated 1. | 0.726 |