| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1R | C1S | ENSBTAP00000069754 | ENSBTAP00000066104 | Complement C1r; Belongs to the peptidase S1 family. | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | 0.999 |
| C1R | C2 | ENSBTAP00000069754 | ENSBTAP00000042824 | Complement C1r; Belongs to the peptidase S1 family. | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. | 0.920 |
| C1R | C3 | ENSBTAP00000069754 | ENSBTAP00000022979 | Complement C1r; Belongs to the peptidase S1 family. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (By similarity). [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.805 |
| C1R | C4A | ENSBTAP00000069754 | ENSBTAP00000009019 | Complement C1r; Belongs to the peptidase S1 family. | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | 0.922 |
| C1R | C4BPA | ENSBTAP00000069754 | ENSBTAP00000073110 | Complement C1r; Belongs to the peptidase S1 family. | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. | 0.626 |
| C1R | CD46 | ENSBTAP00000069754 | ENSBTAP00000065225 | Complement C1r; Belongs to the peptidase S1 family. | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (B [...] | 0.622 |
| C1R | CD55 | ENSBTAP00000069754 | ENSBTAP00000059508 | Complement C1r; Belongs to the peptidase S1 family. | Uncharacterized protein. | 0.737 |
| C1R | CFB | ENSBTAP00000069754 | ENSBTAP00000009800 | Complement C1r; Belongs to the peptidase S1 family. | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. | 0.777 |
| C1R | CFI | ENSBTAP00000069754 | ENSBTAP00000070566 | Complement C1r; Belongs to the peptidase S1 family. | Complement factor I; Belongs to the peptidase S1 family. | 0.445 |
| C1S | C1R | ENSBTAP00000066104 | ENSBTAP00000069754 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement C1r; Belongs to the peptidase S1 family. | 0.999 |
| C1S | C2 | ENSBTAP00000066104 | ENSBTAP00000042824 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. | 0.950 |
| C1S | C3 | ENSBTAP00000066104 | ENSBTAP00000022979 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (By similarity). [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.873 |
| C1S | C4A | ENSBTAP00000066104 | ENSBTAP00000009019 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | 0.954 |
| C1S | C4BPA | ENSBTAP00000066104 | ENSBTAP00000073110 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. | 0.615 |
| C1S | CD46 | ENSBTAP00000066104 | ENSBTAP00000065225 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (B [...] | 0.641 |
| C1S | CD55 | ENSBTAP00000066104 | ENSBTAP00000059508 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Uncharacterized protein. | 0.761 |
| C1S | CFB | ENSBTAP00000066104 | ENSBTAP00000009800 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. | 0.856 |
| C1S | CFI | ENSBTAP00000066104 | ENSBTAP00000070566 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement factor I; Belongs to the peptidase S1 family. | 0.488 |
| C2 | C1R | ENSBTAP00000042824 | ENSBTAP00000069754 | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. | Complement C1r; Belongs to the peptidase S1 family. | 0.920 |
| C2 | C1S | ENSBTAP00000042824 | ENSBTAP00000066104 | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | 0.950 |
