| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SKI | SKIL | ENSBTAP00000053695 | ENSBTAP00000005438 | SKI proto-oncogene. | SKI like proto-oncogene. | 0.995 |
| SKI | SMAD1 | ENSBTAP00000053695 | ENSBTAP00000074456 | SKI proto-oncogene. | Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression; Belongs to the dwarfin/SMAD family. | 0.929 |
| SKI | SMAD2 | ENSBTAP00000053695 | ENSBTAP00000017649 | SKI proto-oncogene. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.895 |
| SKI | SMAD3 | ENSBTAP00000053695 | ENSBTAP00000016728 | SKI proto-oncogene. | Mothers against decapentaplegic homolog. | 0.901 |
| SKI | SMAD4 | ENSBTAP00000053695 | ENSBTAP00000009081 | SKI proto-oncogene. | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] | 0.997 |
| SKI | SMAD5 | ENSBTAP00000053695 | ENSBTAP00000064729 | SKI proto-oncogene. | Mothers against decapentaplegic homolog. | 0.901 |
| SKI | SMAD7 | ENSBTAP00000053695 | ENSBTAP00000043987 | SKI proto-oncogene. | Mothers against decapentaplegic homolog. | 0.721 |
| SKI | SMAD9 | ENSBTAP00000053695 | ENSBTAP00000009982 | SKI proto-oncogene. | Mothers against decapentaplegic homolog. | 0.797 |
| SKI | TGFBR1 | ENSBTAP00000053695 | ENSBTAP00000024010 | SKI proto-oncogene. | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] | 0.459 |
| SKIL | SKI | ENSBTAP00000005438 | ENSBTAP00000053695 | SKI like proto-oncogene. | SKI proto-oncogene. | 0.995 |
| SKIL | SMAD1 | ENSBTAP00000005438 | ENSBTAP00000074456 | SKI like proto-oncogene. | Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression; Belongs to the dwarfin/SMAD family. | 0.734 |
| SKIL | SMAD2 | ENSBTAP00000005438 | ENSBTAP00000017649 | SKI like proto-oncogene. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.917 |
| SKIL | SMAD3 | ENSBTAP00000005438 | ENSBTAP00000016728 | SKI like proto-oncogene. | Mothers against decapentaplegic homolog. | 0.922 |
| SKIL | SMAD4 | ENSBTAP00000005438 | ENSBTAP00000009081 | SKI like proto-oncogene. | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] | 0.998 |
| SKIL | SMAD5 | ENSBTAP00000005438 | ENSBTAP00000064729 | SKI like proto-oncogene. | Mothers against decapentaplegic homolog. | 0.679 |
| SKIL | SMAD7 | ENSBTAP00000005438 | ENSBTAP00000043987 | SKI like proto-oncogene. | Mothers against decapentaplegic homolog. | 0.742 |
| SKIL | SMAD9 | ENSBTAP00000005438 | ENSBTAP00000009982 | SKI like proto-oncogene. | Mothers against decapentaplegic homolog. | 0.650 |
| SKIL | TGFBR1 | ENSBTAP00000005438 | ENSBTAP00000024010 | SKI like proto-oncogene. | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] | 0.587 |
| SKIL | TGFBR2 | ENSBTAP00000005438 | ENSBTAP00000055112 | SKI like proto-oncogene. | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.412 |
| SMAD1 | SKI | ENSBTAP00000074456 | ENSBTAP00000053695 | Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression; Belongs to the dwarfin/SMAD family. | SKI proto-oncogene. | 0.929 |
