| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1R | C1S | ENSBTAP00000069754 | ENSBTAP00000066104 | Complement C1r; Belongs to the peptidase S1 family. | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | 0.999 |
| C1R | C2 | ENSBTAP00000069754 | ENSBTAP00000042824 | Complement C1r; Belongs to the peptidase S1 family. | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. | 0.920 |
| C1R | C4A | ENSBTAP00000069754 | ENSBTAP00000009019 | Complement C1r; Belongs to the peptidase S1 family. | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | 0.922 |
| C1R | CFB | ENSBTAP00000069754 | ENSBTAP00000009800 | Complement C1r; Belongs to the peptidase S1 family. | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. | 0.777 |
| C1R | CRP | ENSBTAP00000069754 | ENSBTAP00000018469 | Complement C1r; Belongs to the peptidase S1 family. | Pentaxin. | 0.668 |
| C1R | MBL1 | ENSBTAP00000069754 | ENSBTAP00000001165 | Complement C1r; Belongs to the peptidase S1 family. | Liver mannan-binding lectin. | 0.883 |
| C1R | MBL2 | ENSBTAP00000069754 | ENSBTAP00000009270 | Complement C1r; Belongs to the peptidase S1 family. | Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). | 0.936 |
| C1R | SERPING1 | ENSBTAP00000069754 | ENSBTAP00000021638 | Complement C1r; Belongs to the peptidase S1 family. | Factor XIIa inhibitor; May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins; Belongs to the serpin family. | 0.997 |
| C1S | C1R | ENSBTAP00000066104 | ENSBTAP00000069754 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement C1r; Belongs to the peptidase S1 family. | 0.999 |
| C1S | C2 | ENSBTAP00000066104 | ENSBTAP00000042824 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. | 0.950 |
| C1S | C4A | ENSBTAP00000066104 | ENSBTAP00000009019 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | 0.954 |
| C1S | CFB | ENSBTAP00000066104 | ENSBTAP00000009800 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. | 0.856 |
| C1S | CRP | ENSBTAP00000066104 | ENSBTAP00000018469 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Pentaxin. | 0.702 |
| C1S | MBL1 | ENSBTAP00000066104 | ENSBTAP00000001165 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Liver mannan-binding lectin. | 0.912 |
| C1S | MBL2 | ENSBTAP00000066104 | ENSBTAP00000009270 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). | 0.950 |
| C1S | SERPING1 | ENSBTAP00000066104 | ENSBTAP00000021638 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | Factor XIIa inhibitor; May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins; Belongs to the serpin family. | 0.999 |
| C2 | C1R | ENSBTAP00000042824 | ENSBTAP00000069754 | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. | Complement C1r; Belongs to the peptidase S1 family. | 0.920 |
| C2 | C1S | ENSBTAP00000042824 | ENSBTAP00000066104 | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). | 0.950 |
| C2 | C4A | ENSBTAP00000042824 | ENSBTAP00000009019 | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. | Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). | 0.986 |
| C2 | CFB | ENSBTAP00000042824 | ENSBTAP00000009800 | Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. | 0.677 |
