Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
TMEM143Transmembrane protein 143. (458 aa)    
Predicted Functional Partners:
PHYHIPL
Phytanoyl-CoA hydroxylase interacting protein-like; May play a role in the development of the central system. Belongs to the PHYHIP family.
      
 0.645
CCDC114
Coiled-coil domain containing 114.
      
 0.639
IQCE
IQ motif containing E.
      
 0.636
TMEM186
Transmembrane protein 186.
      
 0.613
MRPL47
39S ribosomal protein L47, mitochondrial; Belongs to the universal ribosomal protein uL29 family.
      
 0.513
ARMC4
Armadillo repeat containing 4.
      
 0.499
EMP3
Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions; Belongs to the PMP-22/EMP/MP20 family.
      
 0.486
MYL10
Myosin light chain 10.
      
 0.486
TMEM160
Transmembrane protein 160.
      
 0.479
TMEM65
Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity).
      
 0.474
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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