node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F2 | F2R | ENSBTAP00000009406 | ENSBTAP00000026902 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | 0.993 |
F2 | F2RL2 | ENSBTAP00000009406 | ENSBTAP00000001191 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | 0.989 |
F2 | F2RL3 | ENSBTAP00000009406 | ENSBTAP00000012283 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.983 |
F2 | F5 | ENSBTAP00000009406 | ENSBTAP00000023573 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Coagulation factor V heavy chain; Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin; Belongs to the multicopper oxidase family. | 0.988 |
F2 | FGA | ENSBTAP00000009406 | ENSBTAP00000002145 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] | 0.999 |
F2 | FGB | ENSBTAP00000009406 | ENSBTAP00000067912 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] | 0.996 |
F2 | FGG | ENSBTAP00000009406 | ENSBTAP00000008877 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Fibrinogen gamma-B chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enh [...] | 0.995 |
F2 | SERPINC1 | ENSBTAP00000009406 | ENSBTAP00000072452 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). | 0.999 |
F2 | SERPIND1 | ENSBTAP00000009406 | ENSBTAP00000018574 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Serpin family D member 1; Belongs to the serpin family. | 0.997 |
F2 | THBD | ENSBTAP00000009406 | ENSBTAP00000066029 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Thrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. | 0.996 |
F2R | F2 | ENSBTAP00000026902 | ENSBTAP00000009406 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | 0.993 |
F2R | F2RL2 | ENSBTAP00000026902 | ENSBTAP00000001191 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | 0.508 |
F2R | F2RL3 | ENSBTAP00000026902 | ENSBTAP00000012283 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.908 |
F2R | FGG | ENSBTAP00000026902 | ENSBTAP00000008877 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | Fibrinogen gamma-B chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enh [...] | 0.465 |
F2R | THBD | ENSBTAP00000026902 | ENSBTAP00000066029 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | Thrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. | 0.732 |
F2RL2 | F2 | ENSBTAP00000001191 | ENSBTAP00000009406 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | 0.989 |
F2RL2 | F2R | ENSBTAP00000001191 | ENSBTAP00000026902 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | 0.508 |
F2RL2 | F2RL3 | ENSBTAP00000001191 | ENSBTAP00000012283 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.910 |
F2RL3 | F2 | ENSBTAP00000012283 | ENSBTAP00000009406 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | 0.983 |
F2RL3 | F2R | ENSBTAP00000012283 | ENSBTAP00000026902 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. | 0.908 |