node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASNS | FH | ENSBTAP00000068704 | ENSBTAP00000028902 | Asparagine synthetase [glutamine-hydrolyzing]. | Fumarate hydratase. | 0.667 |
ASNS | GLUD1 | ENSBTAP00000068704 | ENSBTAP00000009923 | Asparagine synthetase [glutamine-hydrolyzing]. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.754 |
ASNS | GOT1 | ENSBTAP00000068704 | ENSBTAP00000015873 | Asparagine synthetase [glutamine-hydrolyzing]. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.952 |
ASNS | GOT2 | ENSBTAP00000068704 | ENSBTAP00000009440 | Asparagine synthetase [glutamine-hydrolyzing]. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.971 |
ASNS | GPT2 | ENSBTAP00000068704 | ENSBTAP00000003881 | Asparagine synthetase [glutamine-hydrolyzing]. | Glutamic--pyruvic transaminase 2. | 0.548 |
FH | ASNS | ENSBTAP00000028902 | ENSBTAP00000068704 | Fumarate hydratase. | Asparagine synthetase [glutamine-hydrolyzing]. | 0.667 |
FH | GLUD1 | ENSBTAP00000028902 | ENSBTAP00000009923 | Fumarate hydratase. | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.668 |
FH | GOT1 | ENSBTAP00000028902 | ENSBTAP00000015873 | Fumarate hydratase. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.967 |
FH | GOT2 | ENSBTAP00000028902 | ENSBTAP00000009440 | Fumarate hydratase. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.977 |
FH | GPT | ENSBTAP00000028902 | ENSBTAP00000010309 | Fumarate hydratase. | Alanine aminotransferase 1; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. | 0.915 |
FH | GPT2 | ENSBTAP00000028902 | ENSBTAP00000003881 | Fumarate hydratase. | Glutamic--pyruvic transaminase 2. | 0.910 |
FH | LDHA | ENSBTAP00000028902 | ENSBTAP00000047729 | Fumarate hydratase. | L-lactate dehydrogenase A chain. | 0.847 |
FH | MDH1 | ENSBTAP00000028902 | ENSBTAP00000069808 | Fumarate hydratase. | Malate dehydrogenase, cytoplasmic. | 0.992 |
FH | MDH2 | ENSBTAP00000028902 | ENSBTAP00000012454 | Fumarate hydratase. | Malate dehydrogenase, mitochondrial. | 0.997 |
FH | SDHA | ENSBTAP00000028902 | ENSBTAP00000056370 | Fumarate hydratase. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.999 |
GLUD1 | ASNS | ENSBTAP00000009923 | ENSBTAP00000068704 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Asparagine synthetase [glutamine-hydrolyzing]. | 0.754 |
GLUD1 | FH | ENSBTAP00000009923 | ENSBTAP00000028902 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Fumarate hydratase. | 0.668 |
GLUD1 | GOT1 | ENSBTAP00000009923 | ENSBTAP00000015873 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.982 |
GLUD1 | GOT2 | ENSBTAP00000009923 | ENSBTAP00000009440 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). | 0.988 |
GLUD1 | GPT | ENSBTAP00000009923 | ENSBTAP00000010309 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Alanine aminotransferase 1; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. | 0.966 |