node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTRC | CUL1 | ENSBTAP00000009830 | ENSBTAP00000063991 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | Cullin 1; Belongs to the cullin family. | 0.991 |
BTRC | FBXO2 | ENSBTAP00000009830 | ENSBTAP00000009501 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotransl [...] | 0.927 |
BTRC | FBXO4 | ENSBTAP00000009830 | ENSBTAP00000022583 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | 0.922 |
BTRC | FBXW11 | ENSBTAP00000009830 | ENSBTAP00000066952 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | F-box and WD repeat domain containing 11. | 0.977 |
BTRC | FBXW7 | ENSBTAP00000009830 | ENSBTAP00000064414 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK si [...] | 0.936 |
BTRC | SKP1 | ENSBTAP00000009830 | ENSBTAP00000035184 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.984 |
BTRC | SKP2 | ENSBTAP00000009830 | ENSBTAP00000018036 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | SKP2 protein. | 0.939 |
CUL1 | BTRC | ENSBTAP00000063991 | ENSBTAP00000009830 | Cullin 1; Belongs to the cullin family. | Beta-transducin repeat containing E3 ubiquitin protein ligase. | 0.991 |
CUL1 | FBXO2 | ENSBTAP00000063991 | ENSBTAP00000009501 | Cullin 1; Belongs to the cullin family. | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotransl [...] | 0.866 |
CUL1 | FBXO4 | ENSBTAP00000063991 | ENSBTAP00000022583 | Cullin 1; Belongs to the cullin family. | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | 0.881 |
CUL1 | FBXO6 | ENSBTAP00000063991 | ENSBTAP00000069202 | Cullin 1; Belongs to the cullin family. | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | 0.826 |
CUL1 | FBXW11 | ENSBTAP00000063991 | ENSBTAP00000066952 | Cullin 1; Belongs to the cullin family. | F-box and WD repeat domain containing 11. | 0.996 |
CUL1 | FBXW7 | ENSBTAP00000063991 | ENSBTAP00000064414 | Cullin 1; Belongs to the cullin family. | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK si [...] | 0.964 |
CUL1 | SKP1 | ENSBTAP00000063991 | ENSBTAP00000035184 | Cullin 1; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
CUL1 | SKP2 | ENSBTAP00000063991 | ENSBTAP00000018036 | Cullin 1; Belongs to the cullin family. | SKP2 protein. | 0.999 |
DISP3 | FBXO2 | ENSBTAP00000055350 | ENSBTAP00000009501 | Dispatched RND transporter family member 3. | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotransl [...] | 0.705 |
DISP3 | FBXO6 | ENSBTAP00000055350 | ENSBTAP00000069202 | Dispatched RND transporter family member 3. | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] | 0.508 |
FBXO2 | BTRC | ENSBTAP00000009501 | ENSBTAP00000009830 | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotransl [...] | Beta-transducin repeat containing E3 ubiquitin protein ligase. | 0.927 |
FBXO2 | CUL1 | ENSBTAP00000009501 | ENSBTAP00000063991 | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotransl [...] | Cullin 1; Belongs to the cullin family. | 0.866 |
FBXO2 | DISP3 | ENSBTAP00000009501 | ENSBTAP00000055350 | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotransl [...] | Dispatched RND transporter family member 3. | 0.705 |