node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM10 | PDZD11 | ENSBTAP00000056919 | ENSBTAP00000017091 | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involve [...] | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.444 |
ADAM10 | TSPAN33 | ENSBTAP00000056919 | ENSBTAP00000009542 | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involve [...] | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | 0.853 |
LOC530472 | TSPAN33 | ENSBTAP00000064990 | ENSBTAP00000009542 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | 0.590 |
PDZD11 | ADAM10 | ENSBTAP00000017091 | ENSBTAP00000056919 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involve [...] | 0.444 |
PDZD11 | SLC5A6 | ENSBTAP00000017091 | ENSBTAP00000032888 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.946 |
PDZD11 | TSPAN33 | ENSBTAP00000017091 | ENSBTAP00000009542 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | 0.748 |
PIWIL4 | TSPAN33 | ENSBTAP00000019851 | ENSBTAP00000009542 | Piwi like RNA-mediated gene silencing 4; Belongs to the argonaute family. | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | 0.749 |
PIWIL4 | ZBTB43 | ENSBTAP00000019851 | ENSBTAP00000004465 | Piwi like RNA-mediated gene silencing 4; Belongs to the argonaute family. | Zinc finger and BTB domain containing 43. | 0.425 |
SLC5A6 | PDZD11 | ENSBTAP00000032888 | ENSBTAP00000017091 | Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.946 |
SLC5A6 | TSPAN33 | ENSBTAP00000032888 | ENSBTAP00000009542 | Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | 0.652 |
TM6SF1 | TMEM182 | ENSBTAP00000017175 | ENSBTAP00000049465 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Transmembrane protein 182. | 0.926 |
TM6SF1 | TSPAN33 | ENSBTAP00000017175 | ENSBTAP00000009542 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | 0.841 |
TMEM182 | TM6SF1 | ENSBTAP00000049465 | ENSBTAP00000017175 | Transmembrane protein 182. | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. | 0.926 |
TMEM182 | TSPAN33 | ENSBTAP00000049465 | ENSBTAP00000009542 | Transmembrane protein 182. | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | 0.660 |
TSPAN31 | TSPAN32 | ENSBTAP00000009419 | ENSBTAP00000071109 | Tetraspanin-31. | Tetraspanin 32. | 0.631 |
TSPAN31 | TSPAN33 | ENSBTAP00000009419 | ENSBTAP00000009542 | Tetraspanin-31. | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | 0.569 |
TSPAN32 | TSPAN31 | ENSBTAP00000071109 | ENSBTAP00000009419 | Tetraspanin 32. | Tetraspanin-31. | 0.631 |
TSPAN32 | TSPAN33 | ENSBTAP00000071109 | ENSBTAP00000009542 | Tetraspanin 32. | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | 0.569 |
TSPAN33 | ADAM10 | ENSBTAP00000009542 | ENSBTAP00000056919 | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involve [...] | 0.853 |
TSPAN33 | LOC530472 | ENSBTAP00000009542 | ENSBTAP00000064990 | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 0.590 |