node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTCF | NIPBL | ENSBTAP00000018279 | ENSBTAP00000020129 | CCCTC-binding factor (Zinc finger protein). | Nipped-B protein. | 0.836 |
CTCF | RAD21 | ENSBTAP00000018279 | ENSBTAP00000009607 | CCCTC-binding factor (Zinc finger protein). | Double-strand-break repair protein rad21 homolog; [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression [...] | 0.980 |
CTCF | SMC1A | ENSBTAP00000018279 | ENSBTAP00000023619 | CCCTC-binding factor (Zinc finger protein). | Structural maintenance of chromosomes protein 1A; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and [...] | 0.756 |
CTCF | SMC3 | ENSBTAP00000018279 | ENSBTAP00000043550 | CCCTC-binding factor (Zinc finger protein). | Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement; Belongs to the SMC family. SMC3 subfamily. | 0.868 |
CTCF | STAG1 | ENSBTAP00000018279 | ENSBTAP00000046739 | CCCTC-binding factor (Zinc finger protein). | Stromal antigen 1. | 0.647 |
CTCF | STAG2 | ENSBTAP00000018279 | ENSBTAP00000012029 | CCCTC-binding factor (Zinc finger protein). | Stromal antigen 2. | 0.918 |
CTCF | STAG3 | ENSBTAP00000018279 | ENSBTAP00000068268 | CCCTC-binding factor (Zinc finger protein). | SCD domain-containing protein. | 0.580 |
CTCF | WAPL | ENSBTAP00000018279 | ENSBTAP00000016211 | CCCTC-binding factor (Zinc finger protein). | WAPL cohesin release factor. | 0.721 |
ESPL1 | NIPBL | ENSBTAP00000011761 | ENSBTAP00000020129 | Extra spindle pole bodies like 1, separase. | Nipped-B protein. | 0.661 |
ESPL1 | RAD21 | ENSBTAP00000011761 | ENSBTAP00000009607 | Extra spindle pole bodies like 1, separase. | Double-strand-break repair protein rad21 homolog; [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression [...] | 0.989 |
ESPL1 | SMC1A | ENSBTAP00000011761 | ENSBTAP00000023619 | Extra spindle pole bodies like 1, separase. | Structural maintenance of chromosomes protein 1A; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and [...] | 0.974 |
ESPL1 | SMC1B | ENSBTAP00000011761 | ENSBTAP00000014005 | Extra spindle pole bodies like 1, separase. | Structural maintenance of chromosomes protein. | 0.966 |
ESPL1 | SMC3 | ENSBTAP00000011761 | ENSBTAP00000043550 | Extra spindle pole bodies like 1, separase. | Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement; Belongs to the SMC family. SMC3 subfamily. | 0.993 |
ESPL1 | STAG1 | ENSBTAP00000011761 | ENSBTAP00000046739 | Extra spindle pole bodies like 1, separase. | Stromal antigen 1. | 0.952 |
ESPL1 | STAG2 | ENSBTAP00000011761 | ENSBTAP00000012029 | Extra spindle pole bodies like 1, separase. | Stromal antigen 2. | 0.960 |
ESPL1 | STAG3 | ENSBTAP00000011761 | ENSBTAP00000068268 | Extra spindle pole bodies like 1, separase. | SCD domain-containing protein. | 0.705 |
ESPL1 | WAPL | ENSBTAP00000011761 | ENSBTAP00000016211 | Extra spindle pole bodies like 1, separase. | WAPL cohesin release factor. | 0.935 |
NIPBL | CTCF | ENSBTAP00000020129 | ENSBTAP00000018279 | Nipped-B protein. | CCCTC-binding factor (Zinc finger protein). | 0.836 |
NIPBL | ESPL1 | ENSBTAP00000020129 | ENSBTAP00000011761 | Nipped-B protein. | Extra spindle pole bodies like 1, separase. | 0.661 |
NIPBL | RAD21 | ENSBTAP00000020129 | ENSBTAP00000009607 | Nipped-B protein. | Double-strand-break repair protein rad21 homolog; [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression [...] | 0.999 |