node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNTF | CTF1 | ENSBTAP00000004729 | ENSBTAP00000023537 | Ciliary neurotrophic factor. | Cardiotrophin 1. | 0.837 |
CNTF | FGF2 | ENSBTAP00000004729 | ENSBTAP00000007477 | Ciliary neurotrophic factor. | Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. | 0.809 |
CNTF | IL12RB2 | ENSBTAP00000004729 | ENSBTAP00000012441 | Ciliary neurotrophic factor. | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. On IL12 stimulation, enhances IFN-gamma expression; Belongs to the type I cytokine receptor family. Type 2 subfamily. | 0.782 |
CNTF | IL27RA | ENSBTAP00000004729 | ENSBTAP00000022524 | Ciliary neurotrophic factor. | Interleukin 27 receptor subunit alpha. | 0.826 |
CNTF | IL6ST | ENSBTAP00000004729 | ENSBTAP00000023595 | Ciliary neurotrophic factor. | Interleukin 6 signal transducer. | 0.937 |
CNTF | LIF | ENSBTAP00000004729 | ENSBTAP00000073388 | Ciliary neurotrophic factor. | Leukemia inhibitory factor; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes (By similarity); Belongs to the LIF/OSM family. | 0.838 |
CNTF | LIFR | ENSBTAP00000004729 | ENSBTAP00000069845 | Ciliary neurotrophic factor. | LIF receptor subunit alpha. | 0.995 |
CNTF | OSM | ENSBTAP00000004729 | ENSBTAP00000021515 | Ciliary neurotrophic factor. | Oncostatin-M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G- CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST) (By similarity). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). | 0.783 |
CNTF | OSMR | ENSBTAP00000004729 | ENSBTAP00000072672 | Ciliary neurotrophic factor. | Oncostatin M receptor. | 0.883 |
CTF1 | CNTF | ENSBTAP00000023537 | ENSBTAP00000004729 | Cardiotrophin 1. | Ciliary neurotrophic factor. | 0.837 |
CTF1 | FGF2 | ENSBTAP00000023537 | ENSBTAP00000007477 | Cardiotrophin 1. | Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. | 0.487 |
CTF1 | IL12RB2 | ENSBTAP00000023537 | ENSBTAP00000012441 | Cardiotrophin 1. | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. On IL12 stimulation, enhances IFN-gamma expression; Belongs to the type I cytokine receptor family. Type 2 subfamily. | 0.736 |
CTF1 | IL27RA | ENSBTAP00000023537 | ENSBTAP00000022524 | Cardiotrophin 1. | Interleukin 27 receptor subunit alpha. | 0.729 |
CTF1 | IL6ST | ENSBTAP00000023537 | ENSBTAP00000023595 | Cardiotrophin 1. | Interleukin 6 signal transducer. | 0.933 |
CTF1 | LIF | ENSBTAP00000023537 | ENSBTAP00000073388 | Cardiotrophin 1. | Leukemia inhibitory factor; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes (By similarity); Belongs to the LIF/OSM family. | 0.884 |
CTF1 | LIFR | ENSBTAP00000023537 | ENSBTAP00000069845 | Cardiotrophin 1. | LIF receptor subunit alpha. | 0.979 |
CTF1 | OSM | ENSBTAP00000023537 | ENSBTAP00000021515 | Cardiotrophin 1. | Oncostatin-M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G- CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST) (By similarity). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). | 0.945 |
CTF1 | OSMR | ENSBTAP00000023537 | ENSBTAP00000072672 | Cardiotrophin 1. | Oncostatin M receptor. | 0.907 |
FGF2 | CNTF | ENSBTAP00000007477 | ENSBTAP00000004729 | Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. | Ciliary neurotrophic factor. | 0.809 |
FGF2 | CTF1 | ENSBTAP00000007477 | ENSBTAP00000023537 | Kidney-derived growth factor; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. | Cardiotrophin 1. | 0.487 |