STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRHL1Grainyhead like transcription factor 1. (629 aa)    
Predicted Functional Partners:
ESRP1
Epithelial splicing regulatory protein 1.
   
  
 0.721
ZNF750
Zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression (By similarity).
   
  
 0.639
OVOL1
Putative transcription factor Ovo-like 1; Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).
   
  
 0.631
RIPK4
Receptor interacting serine/threonine kinase 4.
   
 
 0.607
IRF6
Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. It is a key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity); Belongs to the IRF family.
   
 
 0.584
OVOL2
Ovo like zinc finger 2.
   
  
 0.563
NUCKS1
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1.
   
  
 0.547
PYROXD2
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase.
      
 0.534
GLIS2
GLIS family zinc finger 2.
    
 
 0.522
ZFP90
ZFP90 zinc finger protein.
    
 
 0.520
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.