node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEC22B | SNAP23 | ENSBTAP00000072245 | ENSBTAP00000007438 | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.939 |
SEC22B | SNAP25 | ENSBTAP00000072245 | ENSBTAP00000010961 | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (By similarity). Belongs to the SNAP-25 family. | 0.774 |
SEC22B | SNAP29 | ENSBTAP00000072245 | ENSBTAP00000027666 | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. | 0.910 |
SEC22B | STX4 | ENSBTAP00000072245 | ENSBTAP00000009899 | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones (By similarity). | 0.988 |
SEC22B | STX6 | ENSBTAP00000072245 | ENSBTAP00000027262 | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | STX6 protein; Belongs to the syntaxin family. | 0.914 |
SEC22B | VAMP1 | ENSBTAP00000072245 | ENSBTAP00000062791 | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. | 0.776 |
SEC22B | VAMP2 | ENSBTAP00000072245 | ENSBTAP00000059351 | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Belongs to the synaptobrevin family. | 0.780 |
SEC22B | VAMP4 | ENSBTAP00000072245 | ENSBTAP00000073260 | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | Vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity). | 0.858 |
SEC22B | VAMP7 | ENSBTAP00000072245 | ENSBTAP00000066954 | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.885 |
SEC22B | VAMP8 | ENSBTAP00000072245 | ENSBTAP00000032965 | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.890 |
SNAP23 | SEC22B | ENSBTAP00000007438 | ENSBTAP00000072245 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. | 0.939 |
SNAP23 | SNAP25 | ENSBTAP00000007438 | ENSBTAP00000010961 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (By similarity). Belongs to the SNAP-25 family. | 0.623 |
SNAP23 | SNAP29 | ENSBTAP00000007438 | ENSBTAP00000027666 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. | 0.893 |
SNAP23 | STX4 | ENSBTAP00000007438 | ENSBTAP00000009899 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones (By similarity). | 0.999 |
SNAP23 | STX6 | ENSBTAP00000007438 | ENSBTAP00000027262 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | STX6 protein; Belongs to the syntaxin family. | 0.943 |
SNAP23 | VAMP1 | ENSBTAP00000007438 | ENSBTAP00000062791 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. | 0.988 |
SNAP23 | VAMP2 | ENSBTAP00000007438 | ENSBTAP00000059351 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Belongs to the synaptobrevin family. | 0.999 |
SNAP23 | VAMP4 | ENSBTAP00000007438 | ENSBTAP00000073260 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity). | 0.991 |
SNAP23 | VAMP7 | ENSBTAP00000007438 | ENSBTAP00000066954 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.987 |
SNAP23 | VAMP8 | ENSBTAP00000007438 | ENSBTAP00000032965 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.996 |