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GLUD1 protein (Bos taurus) - STRING interaction network
"GLUD1" - Glutamate dehydrogenase 1, mitochondrial in Bos taurus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GLUD1Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (561 aa)    
Predicted Functional Partners:
GLUL
Glutamine synthetase; Essential for proliferation of fetal skin fibroblasts. This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity); Belongs to the glutamine synthetase family (373 aa)
   
 
  0.988
GOT2
Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity) (430 aa)
     
  0.984
GOT1
Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- [...] (413 aa)
     
  0.977
ALDH4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity) (563 aa)
   
  0.971
GPT2
Glutamic pyruvate transaminase (alanine aminotransferase) 2 (523 aa)
   
 
  0.969
MDH2
Bos taurus malate dehydrogenase 2, NAD (mitochondrial) (MDH2), mRNA (277 aa)
   
 
  0.967
GLS2
Glutaminase 2 (liver, mitochondrial) (574 aa)
         
  0.966
GLS
Glutaminase (603 aa)
         
  0.966
NAGS
N-acetylglutamate synthase (534 aa)
   
 
  0.959
CPS1
Uncharacterized protein; Bos taurus carbamoyl-phosphate synthase 1, mitochondrial (CPS1), mRNA (1500 aa)
   
 
  0.954
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, domestic cattle, domestic cow
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