node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACD | MRE11 | ENSBTAP00000025159 | ENSBTAP00000011748 | ACD shelterin complex subunit and telomerase recruitment factor. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.499 |
ACD | NBN | ENSBTAP00000025159 | ENSBTAP00000017598 | ACD shelterin complex subunit and telomerase recruitment factor. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.503 |
ACD | POT1 | ENSBTAP00000025159 | ENSBTAP00000017541 | ACD shelterin complex subunit and telomerase recruitment factor. | Protection of telomeres 1. | 0.991 |
ACD | TERF1 | ENSBTAP00000025159 | ENSBTAP00000044076 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.943 |
ACD | TERF2 | ENSBTAP00000025159 | ENSBTAP00000010016 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomeric repeat binding factor 2. | 0.991 |
ACD | TERF2IP | ENSBTAP00000025159 | ENSBTAP00000020830 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology- directed repair ( [...] | 0.974 |
ACD | TINF2 | ENSBTAP00000025159 | ENSBTAP00000003522 | ACD shelterin complex subunit and telomerase recruitment factor. | TERF1 interacting nuclear factor 2. | 0.991 |
DCLRE1B | POT1 | ENSBTAP00000004713 | ENSBTAP00000017541 | DNA cross-link repair 1B. | Protection of telomeres 1. | 0.454 |
DCLRE1B | SLX4 | ENSBTAP00000004713 | ENSBTAP00000005923 | DNA cross-link repair 1B. | SLX4 structure-specific endonuclease subunit. | 0.701 |
DCLRE1B | TERF1 | ENSBTAP00000004713 | ENSBTAP00000044076 | DNA cross-link repair 1B. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.520 |
DCLRE1B | TERF2 | ENSBTAP00000004713 | ENSBTAP00000010016 | DNA cross-link repair 1B. | Telomeric repeat binding factor 2. | 0.969 |
DCLRE1B | TERF2IP | ENSBTAP00000004713 | ENSBTAP00000020830 | DNA cross-link repair 1B. | Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology- directed repair ( [...] | 0.616 |
DCLRE1B | TINF2 | ENSBTAP00000004713 | ENSBTAP00000003522 | DNA cross-link repair 1B. | TERF1 interacting nuclear factor 2. | 0.485 |
MCPH1 | MRE11 | ENSBTAP00000064656 | ENSBTAP00000011748 | Microcephalin 1. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.637 |
MCPH1 | NBN | ENSBTAP00000064656 | ENSBTAP00000017598 | Microcephalin 1. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.606 |
MCPH1 | TERF2 | ENSBTAP00000064656 | ENSBTAP00000010016 | Microcephalin 1. | Telomeric repeat binding factor 2. | 0.820 |
MRE11 | ACD | ENSBTAP00000011748 | ENSBTAP00000025159 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | ACD shelterin complex subunit and telomerase recruitment factor. | 0.499 |
MRE11 | MCPH1 | ENSBTAP00000011748 | ENSBTAP00000064656 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Microcephalin 1. | 0.637 |
MRE11 | NBN | ENSBTAP00000011748 | ENSBTAP00000017598 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.997 |
MRE11 | POT1 | ENSBTAP00000011748 | ENSBTAP00000017541 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Protection of telomeres 1. | 0.632 |