node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRAF | HRAS | ENSBTAP00000064502 | ENSBTAP00000057060 | B-Raf proto-oncogene, serine/threonine kinase. | HRas proto-oncogene, GTPase. | 0.992 |
BRAF | MRAS | ENSBTAP00000064502 | ENSBTAP00000049244 | B-Raf proto-oncogene, serine/threonine kinase. | Muscle RAS oncogene homolog. | 0.949 |
BRAF | NRAS | ENSBTAP00000064502 | ENSBTAP00000012897 | B-Raf proto-oncogene, serine/threonine kinase. | NRAS proto-oncogene, GTPase. | 0.996 |
BRAF | PPP1CB | ENSBTAP00000064502 | ENSBTAP00000016514 | B-Raf proto-oncogene, serine/threonine kinase. | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] | 0.518 |
BRAF | PPP1CC | ENSBTAP00000064502 | ENSBTAP00000072697 | B-Raf proto-oncogene, serine/threonine kinase. | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] | 0.449 |
BRAF | RAF1 | ENSBTAP00000064502 | ENSBTAP00000005930 | B-Raf proto-oncogene, serine/threonine kinase. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.997 |
BRAF | RRAS | ENSBTAP00000064502 | ENSBTAP00000027944 | B-Raf proto-oncogene, serine/threonine kinase. | Related RAS viral (R-ras) oncogene homolog. | 0.955 |
BRAF | RRAS2 | ENSBTAP00000064502 | ENSBTAP00000015794 | B-Raf proto-oncogene, serine/threonine kinase. | RAS related 2. | 0.940 |
BRAF | SHOC2 | ENSBTAP00000064502 | ENSBTAP00000010138 | B-Raf proto-oncogene, serine/threonine kinase. | Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. | 0.833 |
HRAS | BRAF | ENSBTAP00000057060 | ENSBTAP00000064502 | HRas proto-oncogene, GTPase. | B-Raf proto-oncogene, serine/threonine kinase. | 0.992 |
HRAS | NRAS | ENSBTAP00000057060 | ENSBTAP00000012897 | HRas proto-oncogene, GTPase. | NRAS proto-oncogene, GTPase. | 0.919 |
HRAS | RAF1 | ENSBTAP00000057060 | ENSBTAP00000005930 | HRas proto-oncogene, GTPase. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.983 |
HRAS | RRAS | ENSBTAP00000057060 | ENSBTAP00000027944 | HRas proto-oncogene, GTPase. | Related RAS viral (R-ras) oncogene homolog. | 0.910 |
HRAS | SHOC2 | ENSBTAP00000057060 | ENSBTAP00000010138 | HRas proto-oncogene, GTPase. | Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. | 0.956 |
MRAS | BRAF | ENSBTAP00000049244 | ENSBTAP00000064502 | Muscle RAS oncogene homolog. | B-Raf proto-oncogene, serine/threonine kinase. | 0.949 |
MRAS | PPP1CA | ENSBTAP00000049244 | ENSBTAP00000016111 | Muscle RAS oncogene homolog. | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | 0.641 |
MRAS | PPP1CB | ENSBTAP00000049244 | ENSBTAP00000016514 | Muscle RAS oncogene homolog. | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] | 0.712 |
MRAS | PPP1CC | ENSBTAP00000049244 | ENSBTAP00000072697 | Muscle RAS oncogene homolog. | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] | 0.813 |
MRAS | RAF1 | ENSBTAP00000049244 | ENSBTAP00000005930 | Muscle RAS oncogene homolog. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.948 |
MRAS | SHOC2 | ENSBTAP00000049244 | ENSBTAP00000010138 | Muscle RAS oncogene homolog. | Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. | 0.996 |