STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ATP9BProbable phospholipid-transporting ATPase IIB; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1136 aa)    
Predicted Functional Partners:
TMEM30C
Cell cycle control protein 50C.
    
 
 0.849
SLC66A2
Solute carrier family 66 member 2.
    
 
 0.808
MON2
MON2 homolog, regulator of endosome-to-Golgi trafficking.
   
 
 0.729
TMEM30A
Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. [...]
    
 
 0.709
TMEM30B
Cell cycle control protein; Belongs to the CDC50/LEM3 family.
    
 
 0.703
NEO1
Neogenin 1.
   
  
 0.681
ARL1
ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity).
    
 
 0.572
TMEM175
Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. Belongs to the TMEM175 family.
   
  
 0.554
ATP6V0D2
V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family.
      
 0.532
CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.
      
 0.512
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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