node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FLCN | FNIP1 | ENSBTAP00000010532 | ENSBTAP00000072698 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Folliculin interacting protein 1. | 0.998 |
FLCN | FNIP2 | ENSBTAP00000010532 | ENSBTAP00000070282 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Folliculin interacting protein 2. | 0.999 |
FLCN | LAMTOR3 | ENSBTAP00000010532 | ENSBTAP00000044998 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.843 |
FLCN | LOC539009 | ENSBTAP00000010532 | ENSBTAP00000048674 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Uncharacterized protein. | 0.965 |
FLCN | NPRL2 | ENSBTAP00000010532 | ENSBTAP00000065594 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway; Belongs to the NPR2 family. | 0.873 |
FLCN | RRAGA | ENSBTAP00000010532 | ENSBTAP00000051093 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.988 |
FLCN | RRAGB | ENSBTAP00000010532 | ENSBTAP00000017260 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ras related GTP binding B. | 0.976 |
FLCN | RRAGC | ENSBTAP00000010532 | ENSBTAP00000012331 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ras-related GTP binding C. | 0.986 |
FLCN | RRAGD | ENSBTAP00000010532 | ENSBTAP00000059277 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ras related GTP binding D. | 0.983 |
FLCN | SLC38A9 | ENSBTAP00000010532 | ENSBTAP00000062576 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Solute carrier family 38 member 9. | 0.882 |
FNIP1 | FLCN | ENSBTAP00000072698 | ENSBTAP00000010532 | Folliculin interacting protein 1. | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | 0.998 |
FNIP1 | FNIP2 | ENSBTAP00000072698 | ENSBTAP00000070282 | Folliculin interacting protein 1. | Folliculin interacting protein 2. | 0.968 |
FNIP1 | LAMTOR3 | ENSBTAP00000072698 | ENSBTAP00000044998 | Folliculin interacting protein 1. | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.536 |
FNIP1 | LOC539009 | ENSBTAP00000072698 | ENSBTAP00000048674 | Folliculin interacting protein 1. | Uncharacterized protein. | 0.909 |
FNIP1 | NPRL2 | ENSBTAP00000072698 | ENSBTAP00000065594 | Folliculin interacting protein 1. | GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway; Belongs to the NPR2 family. | 0.543 |
FNIP1 | RRAGA | ENSBTAP00000072698 | ENSBTAP00000051093 | Folliculin interacting protein 1. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.945 |
FNIP1 | RRAGB | ENSBTAP00000072698 | ENSBTAP00000017260 | Folliculin interacting protein 1. | Ras related GTP binding B. | 0.909 |
FNIP1 | RRAGC | ENSBTAP00000072698 | ENSBTAP00000012331 | Folliculin interacting protein 1. | Ras-related GTP binding C. | 0.957 |
FNIP1 | RRAGD | ENSBTAP00000072698 | ENSBTAP00000059277 | Folliculin interacting protein 1. | Ras related GTP binding D. | 0.960 |
FNIP1 | SLC38A9 | ENSBTAP00000072698 | ENSBTAP00000062576 | Folliculin interacting protein 1. | Solute carrier family 38 member 9. | 0.578 |